MELK-8a

Product Name: MELK-8a
CAS No.: 1922153-17-0
Chemical Name: MELK-8a
Synonyms: MELK-8a;MELK-8a Dihydrochloride;1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine;Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-
CBNumber: CB43386495
Molecular Formula: C25H32N6O
Formula Weight: 432.56
MOL File: 1922153-17-0.mol

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MELK-8a Property

Boiling point:: 596.4±50.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 3 mg/mL (5.93 mM);Water: 22 mg/mL (43.52 mM);Ethanol: Insoluble
form: Solid
pka: 10.28±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC10015
Product name: MELK-8a
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC10015
Product name: MELK-8a
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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MELK-8a Chemical Properties,Usage,Production

Uses

MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].

References

[1] B Barry Touré, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59(10):4711-23. DOI:10.1021/acs.jmedchem.6b00052

MELK-8a Preparation Products And Raw materials

Raw materials

Preparation Products

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MELK-8a Suppliers

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1922153-17-0, MELK-8aRelated Search:

MELK-8a

Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-

1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine

MELK-8a Dihydrochloride

1922153-17-0