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APAMIN

Product Name
APAMIN
CAS No.
24345-16-2
Chemical Name
APAMIN
Synonyms
APAMIN;apamine;APAMIN, BEE VENOM;Apamin, ≥97% (HPLC);APAMIN FROM BEE VENOM;CNCKAPETALCARRCQQH-NH2;Ro 23-6721/Apamin TFA Salt;APAMIN FROM HONEY BEE VENOM;Apamin (trifluoroacetate salt);M.W. 2027.34 C79H131N31O24S4
CBNumber
CB4342708
Molecular Formula
C79H131N31O24S4
Formula Weight
2027.34
MOL File
24345-16-2.mol
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APAMIN Property

Boiling point:
847.17°C (rough estimate)
Density 
1.63
refractive index 
1.5530 (estimate)
storage temp. 
-20°C
solubility 
0.05 M acetic acid: 5 mg/mL, clear, colorless to faintly yellow
form 
White solid with dark tan
color 
White to off-white
biological source
synthetic
Water Solubility 
Soluble to 1 mg/ml in water
Merck 
13,732
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Safety

Safety Statements 
22-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
CD6899900
F 
3-10
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 i.v. in mice: 4 mg/kg (Habermann, Reiz); LD50 intracerebroventricularly in mice: 12 ng/animal (Labbé-Jullié)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1289
Product name
Apamin
Purity
from bee venom, ≥95% (HPLC)
Packaging
0.5mg
Price
$298
Updated
2024/03/01
Sigma-Aldrich
Product number
A9459
Product name
Apamin
Purity
synthetic, ≥97% (HPLC)
Packaging
0.5mg
Price
$400
Updated
2024/03/01
Sigma-Aldrich
Product number
178270
Product name
Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem
Purity
Polypeptide neurotoxin known to pass through the blood-brain barrier.
Packaging
500μg
Price
$182
Updated
2024/03/01
Alfa Aesar
Product number
J60961
Product name
Apamin
Packaging
0.5mg
Price
$168
Updated
2021/12/16
Cayman Chemical
Product number
17082
Product name
Apamin (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$160
Updated
2024/03/01
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APAMIN Chemical Properties,Usage,Production

Chemical Properties

Small, highly potent, highly basic polypeptide.

Uses

Apamin has been used:

  • As a selective inhibitor of small conductance (SKCa) channels in HEK cells.
  • To inhibit endothelium-derived relaxing factor (EDHF) mediated responses.
  • To block small-conductance Ca2-activated K current (ISK) in electrophysiological studies in hyperstriatum ventrale, pars caudalis (HVc) neurons.

Definition

Occurs in the venom of the honey bee, Apis mellifera; molecular weight of 2027.38.

General Description

Apamin is a bee venom component and is strongly basic in nature. It has 18 amino acid residues and two disulphide bonds.

Hazard

Central nervous system poison able to cross the blood–brain barrier; neurotoxic; poison.

Biochem/physiol Actions

Apamin is a neurotoxin which can pass the blood-brain barrier. In human, it might cause peripheral nerve dysfunction, mainly seen after bee stings.

Safety Profile

Poison by intravenous, parenteral,intracerebral, and intraperitoneal routes. When heated todecomposition it emits toxic fumes of SOx and NOx.

Enzyme inhibitor

This bee venom octadecapeptide toxin (FW = 2027.34 g/mol; CAS 24345- 16-2; NCBI Reference Sequence: NP_001011612.1) potently blocks the small-conductance Ca 2+ -activated potassium ion (or SK) channels hSK1 as well as rSK2, with IC50 values of 3.3 nM and 83 pM. It shows greater effectiveness at the SK2 channel (IC50 = 0.06-0.4 nM) than SK1 (IC50 = 1- 12 nM). SK3 (IC50 = 1-13 nM), and SK4 (IC50 = 1 μM) channels, and is active against channels within neurons, vascular endothelium, bladder smooth muscle, and certain cancers. Apamin does not inhibit human cardiac Na + current, L-type Ca 2+ current or other major K+ currents. Structurally, apamin forms a stable structure, consisting of a C-terminal a- helix and two reverse turns, that is stabilized by two disulfide bonds connecting Cys-1 to Cys-11 and Cys-3 to Cys-15. A minor constituent of venom of the bee (Apis mellifera), apamin amounts to only 2-3% (w/w) of its dry venom. The smallest known neurotoxic polypeptide, apamin is derived by proteolytic processing of the 48-residue pre-pro-protein. The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon.

storage

-20°C (desiccate)

APAMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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APAMIN Suppliers

China 113 France 2 Germany 3 India 4 Japan 2 Switzerland 2 United Kingdom 4 United States 24 Global 154
3B Pharmachem (Wuhan) International Co.,Ltd.
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GL Biochem (Shanghai) Ltd
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Chemsky (shanghai) International Co.,Ltd
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ShangHai YuanYe Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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View Lastest Price from APAMIN manufacturers

Career Henan Chemical Co
Product
Apamin 24345-16-2
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

24345-16-2, APAMINRelated Search:

Glibenclamide Nicorandil CHARYBDOTOXIN TRAM-34 5-HYDROXYDECANOIC ACID SODIUM SALT CLOFILIUM TOSYLATE Gabapentin-lactam PAXILLINE N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE APAMIN Honey apamin receptor APAMIN, ALEXA FLUOR(R) 488 CONJUGATE APAMIN, BODIPY(R) FL CONJUGATE APAMIN (DRY ICE) Kca2.2, SK2, Kcnn2, SKCa2 (Apamin-Sensitive Small Conductance Ca2+ -dependent K+ Channel), Rabbit anti-Rat, WB/IH ANTI-POTASSIUM CHANNEL SK2 (APAMIN-SENSITIVE CONDUCTANCE CA2+-DEPENDENT K+ CHANNEL, KCA2, KCNN2, SKCA2) APAMIN, [125I]-HIS18-NH2

  • Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem
  • APAMIN (HONEYBEE, APIS MELLIFERA)
  • H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15)
  • H-+CYS-ASN-++CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-+CYS-ALA-ARG-ARG-++CYS-GLN-GLN- HIS-NH2
  • H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2
  • H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2 (DISULFIDE BRIDGE: 1-11, 3-15)
  • CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2
  • CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-CYS-GLN-GLN-HIS-NH2
  • [CYS-ASN-(CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS]CYCL-ALA-ARG-ARG-CYS)CYCL-GLN-GLN-HIS-NH2
  • CNCKAPETALCARRCQQH-NH2
  • CNCKAPETALCARRCQQH-NH2 (DISULFIDE BRIDGE: 1-11,3-15)
  • APAMIN
  • APAMIN, BEE VENOM
  • APAMIN (HONEY BEE, APIS MELIFERA)
  • apamine
  • APAMIN FROM BEE VENOM
  • APAMIN FROM HONEY BEE VENOM
  • Apamin, ≥97% (HPLC)
  • Apamin (trifluoroacetate salt)
  • M.W. 2027.34 C79H131N31O24S4
  • L-Cys-L-Asn-L-Cys-L-Lys-L-Ala-L-Pro-L-Glu-L-Thr-L-Ala-L-Leu-L-Cys-L-Ala-L-Arg-L-Arg-L-Cys-L-Gln-L-Gln-L-His-NH2
  • CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG- ARG-CYS-GLN-GLN-HIS-NH2(DISULFIDE BRIDGE:CYS1-CYS11, CYS3-CYS15)
  • L-Cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide cyclic (1-11) (3-15)-bis(disulfide) = Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-leu-Cyc-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
  • Apamin, blocker of small conductance Ca2+-activated K+ channels
  • Ro 23-6721/Apamin TFA Salt
  • 24345-16-2
  • C79H131N31O24S4
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