CYTIDINE 5'-DIPHOSPHOCHOLINE
Description- Product Name
- CYTIDINE 5'-DIPHOSPHOCHOLINE
- CAS No.
- 987-78-0
- Chemical Name
- CYTIDINE 5'-DIPHOSPHOCHOLINE
- Synonyms
- CITICOLINE;CDP-CHOLINE;citicholine;CYTIDINE DIPHOSPHATE CHOLINE;Reagin;somazina;Audes;cereb;Rexort;CDPC-H
- CBNumber
- CB4343598
- Molecular Formula
- C14H26N4O11P2
- Formula Weight
- 488.33
- MOL File
- 987-78-0.mol
CYTIDINE 5'-DIPHOSPHOCHOLINE Property
- Melting point:
- >185°C (dec.)
- alpha
- D25 +19.0° (c = 0.86 in H2O)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Water (Sparingly)
- pka
- 4.4(at 25℃)
- form
- Solid
- color
- White
- Stability:
- Moisture Sensitive
- InChIKey
- RZZPDXZPRHQOCG-APGYLPRWNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O |&1:1,2,3,21,r|
- LogP
- -7.070 (est)
- CAS DataBase Reference
- 987-78-0(CAS DataBase Reference)
Safety
- Toxicity
- LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C998313
- Product name
- Cytidine5''-Diphosphocholine
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C998313
- Product name
- Cytidine5''-Diphosphocholine
- Packaging
- 2.5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- K771
- Product name
- Citicoline
- Packaging
- 25g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- FC63074
- Product name
- Cytidine 5'-diphosphocholine
- Packaging
- 50g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- C6983
- Product name
- Citicoline
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
CYTIDINE 5'-DIPHOSPHOCHOLINE Chemical Properties,Usage,Production
Description
Citicoline whose chemical name choline cytosine nucleoside-5'-diphosphate monosodium salt, is a precursor for lecithin biosynthesis, and when brain function declines, the content of lecithin in brain tissue is significantly reduced.
Originator
Nicholin,Cyanamid,Italy,1971
Uses
Cytidine 5'-Diphosphocholine is used as antidepressant, 5HT uptake inhibitor.
Definition
ChEBI: CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+).
Manufacturing Process
A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a
composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'-
monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of
acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml
of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96
mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at
30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated
at a concentration of 3.8 mg/ml in the culture liquor.
The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate
choline, obtained by removing solid matters from the culturing liquor, was
adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed
through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic
acid type). After washing the resin with water, a formic acid solution was
passed through the column with gradual increase in the concentration of
formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was
collected by elution according to the so-called gradient elution method and
absorbed onto carbon powders. Then, elution was effected with acetone, and
the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline
powders were obtained.
Therapeutic Function
Cerebral circulation stimulant
CYTIDINE 5'-DIPHOSPHOCHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CYTIDINE 5'-DIPHOSPHOCHOLINE manufacturers
- Product
- Citicoline 987-78-0
- Price
- US $1.00-9.90/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-04-11
- Product
- Citicoline 987-78-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-30
- Product
- Cytidine 5′ -Diphosphocholine 987-78-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-30