FUBERIDAZOLE Property

Melting point:

310-312℃

Boiling point:

318.14°C (rough estimate)

Density 

1.1820 (rough estimate)

vapor pressure 

<1 x 10^-3Pa (20 °C)

refractive index 

1.5300 (estimate)

storage temp. 

0-6°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

4.6 (base)

Water Solubility 

200 mg l^-1 (pH 4), 71 mg l^-1 (pH 7) at 20 °C

color 

Off-White to Pale Beige

BRN 

153833

LogP

2.670

CAS DataBase Reference

3878-19-1(CAS DataBase Reference)

EPA Substance Registry System

Fuberidazole (3878-19-1)

Safety

Hazard Codes 

Xn,N,T

Risk Statements 

22-50/53-23-21-48/22-43-40-21/22

Safety Statements 

22-60-61-45-36/37

RIDADR 

2588

WGK Germany 

3

RTECS 

DD9010000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H317May cause an allergic skin reaction

H330Fatal if inhaled

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

FUBERIDAZOLE Chemical Properties,Usage,Production

Description

Fuberidazole is a crystalline powder.Molecular weight=184.21; Melting point=285℃(decomposition). Hazard Identification (based on NFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0. Very slightly soluble in water.

Chemical Properties

Fuberidazole is a crystalline powder.

Uses

Fuberidazole is a benzimidazole based fungicide used as a fungicidal seed treatment of barley.

Uses

Fuberidazole is a systemic fungicide used in cereal seed dressing to control a variety of soil and seed borne diseases caused by Fusarium spp. It is also used as an anthelmintic and an inhibitor of enteroviruses.

Definition

ChEBI: A ring assembly consisting of benzimidazole substituted at position 2 by a 2-furyl group. A fungicide used as a seed treatment to control Fusarium spp. in cereals.

General Description

Crystalline powder. Used in cereal seed dressing and fungicidal non-mercurial seed dressing with special action against fusarium. Not registered as a pesticide in the U.S.

Reactivity Profile

FUBERIDAZOLE is a benzimidazole and behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides

Health Hazard

FUBERIDAZOLE is classified as moderately toxic. Its probable oral lethal dose in humans is 0.5-5 g/kg or between 1 ounce and 1 pint for a150 lb. person.

Fire Hazard

When heated to decomposition, FUBERIDAZOLE emits toxic fumes of nitrogen oxides.

Agricultural Uses

Fungicide, Seed treatment: Uses include cereal seed dressing; and fungicidal non-mercurial seed dressing with special action against fusarium. Not registered as a pesticide for use in the U.S. Registered for use in EU countries.

Trade name

BAYCOR®; BAYER 33172®; BAYTAN®; BAYTAN® FS; ICI BAYTAN®; NEOVORONIT®; SIBUTOL®; SIBUTROL®; VORONIT®; VORONITE®; W VII/117®

Potential Exposure

Fuberidazole, a benzimidazole, uses include cereal seed dressing; and fungicidal, nonmercurial seed dressing with special action against fusarium. Not reg istered as a pesticide in the U.S.A.

First aid

: If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

Metabolic pathway

Limited information is available describing the degradation and metabolic fate of fuberidazole. Information presented below was abstracted mainly from the Pesticide Manual (PM). The major degradation pathways observed include rearrangement of the fury1 moiety under UV light irradiation, hydrolysis and hydroxylation reactions in mammalian systems.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area.

Shipping

UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Degradation

Fuberidazole (1) is stable to hydrolysis in pure water and sensitive to light with a half-life (DT₅₀) of ca. 15 min (PM).
Photolysis (at 313 nm using a high pressure Hg lamp) of fuberidazole was much faster for the protonated state as compared to the neutral state (Melo et al., 1994), probably via a cyclopropanyl ketone intermediate (see Scheme 1). Reaction of this intermediate with either water or methanol yielded benzimidazole-2-carboxylic acid (2) or its methyl ester (3), methyl 4-oxo-4-(benzimidazol-2-yl)crotonate( 4, both the cis and trans isomers) and 1-methoxybenzimidazole (5) as major degradates (Melo et al., 1992). Benzimidazole (6) and 2,2'-bibenzimidazole (7) were also detected.

Incompatibilities

Incompatible with acid halides, anhydrides, epoxides, halogenated organics, isocyanates, peroxides, phenols (acidic).

Waste Disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by follow ing package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.