ChemicalBook > CAS DataBase List > PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH

Product Name: PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
CAS No.: 112208-00-1
Chemical Name: PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
Synonyms: sine;P 3C;Pam3CSK4;Pam3CSK41;Pam3CysSK4;Pam3Cys-SKKKK;Pam3Cys-Ser-(Lys)4;PaM3Cys-Ser-(Lys)4 . 3HCl;PAM3-CYS-SER-LYS-LYS-LYS-LYS-OH;PamCys-Ser-(Lys), Hydrochloride
CBNumber: CB4345219
Molecular Formula: C81H156N10O13S
Formula Weight: 1510.23
MOL File: 112208-00-1.mol

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PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Property

Boiling point:: 1408.0±65.0 °C(Predicted)
Density: 1.054±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble to 1 mg/ml in 50% Ethanol / H2O
form: Lyophilized solid
pka: 3.27±0.10(Predicted)
Water Solubility: water: 2mg/mL

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506350
Product name: PamCys-Ser-(Lys), Hydrochloride
Packaging: 2mg
Price: $504
Updated: 2025/07/31

Tocris

Product number: 4633
Product name: Pam3CSK4
Packaging: 1
Price: $182
Updated: 2021/12/16

Usbiological

Product number: 256160
Product name: Pam3CSK4
Packaging: 1mg
Price: $432
Updated: 2021/12/16

Usbiological

Product number: 256161
Product name: Pam3CSK4
Packaging: 100ug
Price: $460
Updated: 2021/12/16

ApexBio Technology

Product number: B5662
Product name: Pam3CSK4
Packaging: 1mg
Price: $274
Updated: 2021/12/16

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PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Chemical Properties,Usage,Production

Uses

Pam3Cys-Ser-(Lys)4, Hydrochloride has been used to stimulate MODE-K cells to access its effects on epithelial neuropilin-1 (NRP1) protein expression. It has been used as a toll-like receptor 2 (TLR2) ligand to study TLR2 functionalities.

General Description

A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
A cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.

Biological Activity

pam3csk4 is an agonist of toll-like receptor 1/2 (tlr1/2) [1].toll-like receptors (tlrs) are proteins that play an important role in the innate immune system. tlrs are mainly expressed in sentinel cells that recognize molecules derived from microbes and then activate immune cell responses.pam3csk4 is a tlr1/2 agonist. pam3csk4 increased tyrosine phosphorylation of plcγ2 and the adaptor protein lat in a syk- and src-dependent way. also, pam3csk4 evoked platelet activation [1].in a mouse rhinitis model sensitized to dermatophagoides farinae allergen, pam3csk4 significantly improved the nasal allergic symptoms and reduced total inflammation cells and the eosinophils in bronchoalveolar lavage fluid (balf). also, pam3csk4 significantly increased ifn-γ release and decreased the levels of il-13 and total ige [2]. pam3csk4 induced the production of both no and tnf-ɑ by macrophages [3]. in a murine asthma model challenged with ova, pam3csk4 significantly reduced eosinophilia and total inflammatory cell infiltrate in balf and inhibited the secretion of il-4 and il-5 induced by ova. also, pam3csk4 reduced the level of ige and increased the production of il-12 [4].

in vivo

Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice^[3].

Animal Model:	Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2^tm1Kir/J (TLR2 -deficient) mice^[3]
Dosage:	5 mg/kg
Administration:	Intraperitoneally (i.p.); once a day for 9 days
Result:	After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.

IC 50

TLR1; TLR2

storage

Store at -20°C

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Suppliers

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View Lastest Price from PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH manufacturers

BOC Sciences

Product: Pam3CSK41 112208-00-1
Price: US $398.00/mg
Min. Order: 5mg
Purity: 98%
Supply Ability: 100mg
Release date: 2021-05-06

112208-00-1, PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OHRelated Search:

LYS-LYS-LYS H-LYS-LYS-OH 2HCL 2-MERCAPTOETHYL OCTANOATE GLY-LYS HYDROCHLORIDE PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH H-ALA-ALA-LYS-OH HCL H-ALA-LYS-OH HCL H-LYS-GLY-GLY-OH 2HCL H2O LYS-LYS-LYS-LYS H-LYS-GLY-OH HCL

PAM3-CYS-SER-LYS-LYS-LYS-LYS-OH

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH

PamCys-Ser-(Lys), Hydrochloride

n-palmitoyl-s-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-ly

sine

N-palmitoyl-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-lysine

PaM3Cys-Ser-Lys-Lys-Lys-Lys-OH, PaM3CSK4

PaM3Cys-Ser-(Lys)4 . 3HCl

P 3C

Pam3CSK4

Pam3CysSK4

S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine

Pam3Cys-SKKKK

Pam3Cys-Ser-(Lys)4

L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-

Pam3CSK41

(2S)-6-Amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2R)-3-{[2,3-bis(hexadecanoyloxy)propyl]sulfanyl}-2-hexadecanamidopropanamido]-3-hydroxypropanamido]hexanamido]hexanamido]hexanamido]hexanoic acid

Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist

112208-00-1

C81H156N10O13S

Pharmaceutical