L-655,708

ChemicalBook > CAS DataBase List > L-655,708

Product Name: L-655,708
CAS No.: 130477-52-0
Chemical Name: L-655,708
Synonyms: MSD;L-655,708;L 655708,L655708;ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg)
CBNumber: CB4345633
Molecular Formula: C18H19N3O4
Formula Weight: 341.36
MOL File: 130477-52-0.mol

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L-655,708 Property

Melting point:: 175-176 °C
Boiling point:: 584.4±50.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: 6 mg/mL
form: powder
pka: 1.49±0.20(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L9787
Product name: L-655,708
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: L9787
Product name: L-655,708
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $522
Updated: 2024/03/01

Cayman Chemical

Product number: 30322
Product name: L-655,708
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 30322
Product name: L-655,708
Packaging: 50mg
Price: $570
Updated: 2024/03/01

Cayman Chemical

Product number: 30322
Product name: L-655,708
Packaging: 10mg
Price: $167
Updated: 2024/03/01

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L-655,708 Chemical Properties,Usage,Production

Uses

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

Biological Activity

Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Biochem/physiol Actions

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.

storage

Desiccate at +4°C

L-655,708 Preparation Products And Raw materials

Raw materials

Preparation Products

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130477-52-0, L-655,708Related Search:

[3H]-L-655,708,L-655,708, [1',1',1'-3H] 2-(1H-IMIDAZOL-1-YL)BENZENECARBOXAMIDE 2-IMIDAZOL-1-YL-BENZALDEHYDE 4-(5-METHYL-1H-IMIDAZOL-1-YL)PHENOL 4-(1H-IMIDAZOL-4-YL)-BUTYLAMINE 1-[2-(1H-IMIDAZOL-1-YL)PHENYL]METHANAMINE L-655,708

ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE

L-655,708

11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER

11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester

Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate

MSD

9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg)

9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-

(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate

L 655708,L655708

130477-52-0

GABA/Glycine receptor