PD 404182
- Product Name
- PD 404182
- CAS No.
- 72596-74-8
- Chemical Name
- PD 404182
- Synonyms
- PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-;3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine;6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
- CBNumber
- CB4347334
- Molecular Formula
- C11H11N3S
- Formula Weight
- 217.29
- MOL File
- Mol file
PD 404182 Property
- Boiling point:
- 366.8±25.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥22 mg/mL, soluble
- pka
- 6.27±0.20(Predicted)
- form
- powder
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P218370
- Product name
- PD404182
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- P218370
- Product name
- PD404182
- Packaging
- 50mg
- Price
- $795
- Updated
- 2021/12/16
- Product number
- P218370
- Product name
- PD404182
- Packaging
- 100mg
- Price
- $1400
- Updated
- 2021/12/16
- Product number
- API0008474
- Product name
- PD-404,182
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $610.88
- Updated
- 2021/12/16
- Product number
- 001639
- Product name
- PD404182
- Packaging
- 004
- Price
- $850
- Updated
- 2021/12/16
PD 404182 Chemical Properties,Usage,Production
Uses
PD 404182 is an inhibitor of SARS-CoV-2
Enzyme inhibitor
This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.