ChemicalBook > CAS DataBase List > 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE

3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE

Product Name
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE
CAS No.
340267-36-9
Chemical Name
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE
Synonyms
CAY10404;CAY10404, 10 mM in DMSO;3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T;3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE;3-(4-methylsulfonylphenyl)-4-phenyl-5-(trifluoromethyl)-1,2-oxazole;Isoxazole, 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-;Bcl-XL,CAY10404,cancer,COX,anti-inflammatory,Bcl-2,Apoptosis,Akt,H-1703,Cyclooxygenase,NSCLC,CAY 10404,H-358,inhibit,cell,pGSK-3β,H-460,analgesic,MAPK,CAY-10404,cyclooxygenase-2,lung,anti-cancer,Inhibitor,Non-small,Protein kinase B,pAkt,PKB
CBNumber
CB4355964
Molecular Formula
C17H12F3NO3S
Formula Weight
367.34
MOL File
Mol file
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3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE Property

storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);272.23(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70210
Product name
CAY10404
Purity
≥98%
Packaging
1mg
Price
$23
Updated
2024/03/01
Cayman Chemical
Product number
70210
Product name
CAY10404
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
70210
Product name
CAY10404
Purity
≥98%
Packaging
10mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
70210
Product name
CAY10404
Purity
≥98%
Packaging
50mg
Price
$765
Updated
2024/03/01
ChemScene
Product number
CS-0082717
Product name
CAY10404
Purity
99.79%
Packaging
5mg
Price
$100
Updated
2021/12/16
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3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE Chemical Properties,Usage,Production

Uses

CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM and a selectivity index (SI; COX-1 IC50/COX-2 IC50) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities[1][2][3].

Definition

ChEBI: Isoxazole, 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)- is a sulfonic acid derivative.

in vivo

CAY10404 (50 mg/kg/day; ip; for 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury[2].

Animal Model:Adult male C57Bl/6J mice weighing 24-30 g[2]
Dosage:50 mg/kg
Administration:IP; daily; for 4 days
Result:Attenuated cyclooxygenase activity, significantly decreasing BAL PGE2 and 6-keto PGF1α.
Decreased lung inflammation in HTV mice (high tidal volume; 20 ml/kg; for 4 hours) and attenuates ventilator-induced lung injury.

IC 50

COX-2: 1 nM (IC50); COX-1: >500 μM (IC50)

References

[1] A G Habeeb, et al. Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity. J Med Chem. 2001 Aug 30;44(18):2921-7. DOI:10.1021/jm0101287
[2] Joshua A Robertson, et al. The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury. Am J Respir Cell Mol Biol. 2012 Sep;47(3):387-94. DOI:10.1165/rcmb.2011-0005OC
[3] Yongseon Cho, et al. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009 Aug;14(6):850-8. DOI:10.1111/j.1440-1843.2009.01563.x

3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE Suppliers

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340267-36-9, 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLERelated Search:


  • 3-(4-methylsulfonylphenyl)-4-phenyl-5-(trifluoromethyl)-1,2-oxazole
  • CAY10404
  • 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE
  • Isoxazole, 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-
  • 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T
  • Bcl-XL,CAY10404,cancer,COX,anti-inflammatory,Bcl-2,Apoptosis,Akt,H-1703,Cyclooxygenase,NSCLC,CAY 10404,H-358,inhibit,cell,pGSK-3β,H-460,analgesic,MAPK,CAY-10404,cyclooxygenase-2,lung,anti-cancer,Inhibitor,Non-small,Protein kinase B,pAkt,PKB
  • CAY10404, 10 mM in DMSO
  • 340267-36-9