(5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID
- Product Name
- (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID
- CAS No.
- 475275-69-5
- Chemical Name
- (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID
- Synonyms
- oro-2-methoxypyridine-4-boronic acid;2-methoxy-5-chloropyridine-4-boronic acid;5-CHLORO-2-METHOXY-PYRIDINE-4-BORONIC ACID;(5-Chloro-2-Methoxy-4-pyridyl)boronic acid;(5-Chloro-2-methoxypyridin-4-yl)boronicaci;5-chlorine-2-methoxy-4-pyridine boronic acid;(5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID;5-CHLORO-2-METHOXYPYRIDIN-4-YL-4-BORONIC ACID;Boronic acid, B-(5-chloro-2-methoxy-4-pyridinyl)-;Boronic acid, (5-chloro-2-methoxy-4-pyridinyl)- (9CI)
- CBNumber
- CB4372848
- Molecular Formula
- C6H7BClNO3
- Formula Weight
- 187.39
- MOL File
- 475275-69-5.mol
(5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID Property
- Boiling point:
- 347.6±52.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 6.82±0.58(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C427938
- Product name
- 5-Chloro-2-methoxypyridine-4-boronicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C427938
- Product name
- 5-Chloro-2-methoxypyridine-4-boronicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C427938
- Product name
- 5-Chloro-2-methoxypyridine-4-boronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- BOR0003761
- Product name
- 5-CHLORO-2-METHOXY-PYRIDINE-4-BORONIC ACID
- Purity
- 97.00%
- Packaging
- 5G
- Price
- $1899.98
- Updated
- 2021/12/16
- Product number
- FC51258
- Product name
- (5-Chloro-2-methoxypyridin-4-yl)boronic acid
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
(5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID Chemical Properties,Usage,Production
Uses
5-Chloro-2-methoxypyridine-4-boronic acid
Synthesis
13473-01-3
121-43-7
475275-69-5
Under nitrogen protection, 300 g of anhydrous tetrahydrofuran was added to the reaction flask with stirring turned on, followed by the addition of 17 g of 2-methoxy-5-chloropyridine and cooling of the reaction system to -30 °C. Slowly 70mL of 2.0M n-butyllithium dichloromethane solution was added dropwise. After the dropwise addition was completed, stirring was continued for 30 minutes, and then 26 g of 1,4,7-trimethyl-1,4,7-triazacyclononane was slowly added dropwise. After the reaction mixture was kept at -30°C for 2 hours, 26 mL of trimethyl borate was added slowly dropwise and stirring was continued for 1 hour. Subsequently, the reaction system was slowly warmed to room temperature and stirred for 1 hour. 400 g of concentrated hydrochloric acid was added to the reaction mixture and stirred for 1 hour for hydrolysis reaction. Stirring was stopped and allowed to stand for layering. The organic layer was separated and the aqueous layer was extracted three times with 100 g of petroleum ether. All organic layers were combined, dried with 50 g of anhydrous sodium sulfate and filtered. The filtrate was concentrated to dryness under reduced pressure to give 16 g of the target product 5-chloro-2-methoxy-4-pyridineboronic acid.
References
[1] Patent: CN102718785, 2016, B. Location in patent: Paragraph 0038; 0039
(5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID manufacturers
- Product
- (5-CHLORO-2-METHOXYPYRIDIN-4-YL)BORONIC ACID 475275-69-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg;5kg;100kg
- Release date
- 2019-07-04