ChemicalBook > CAS DataBase List > DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE

DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE

Product Name
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
CAS No.
150113-99-8
Chemical Name
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
Synonyms
FURIN INHIBITOR I;DECANOYL-RVKR-CMK;DECANOYL-ARG-VAL-LYS-ARG-CMK;Furin Inhibitor I, Dec-RVKR-CMK;Decanoyl-Arg-Val-Lys-Arg-CMK·TFA;DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE;Furin Convertase Inhibitor ( Chloromethylketone);L-Lysinamide, N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
CBNumber
CB4374716
Molecular Formula
C34H66ClN11O5
Formula Weight
744.41
MOL File
150113-99-8.mol
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DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Property

Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
Soluble in H2O
form 
crystalline solid
pka
13.32±0.46(Predicted)
Water Solubility 
Soluble to 1 mg/ml in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
344930
Product name
Furin Inhibitor I
Purity
Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.
Packaging
1mg
Price
$230
Updated
2024/03/01
Sigma-Aldrich
Product number
344930
Product name
Furin Inhibitor I
Purity
Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.
Packaging
1MG
Price
$223
Updated
2023/06/20
Cayman Chemical
Product number
14965
Product name
Furin Inhibitor I
Purity
≥95%
Packaging
500μg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
14965
Product name
Furin Inhibitor I
Purity
≥95%
Packaging
1mg
Price
$157
Updated
2024/03/01
Cayman Chemical
Product number
14965
Product name
Furin Inhibitor I
Purity
≥95%
Packaging
5mg
Price
$728
Updated
2024/03/01
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DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Chemical Properties,Usage,Production

Uses

N2-(1-Oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-lysinamide is a Furin inhibitor that may be used in the inhibition of the Chikungunya virus (CHIKV), a mosquito-transmitted Alphavirus that causes in humans an acute infection characterized by polyarthralgia, fever, myalgia, and headache

Definition

ChEBI: Decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone is a tetrapeptide consisting of N-decanoyl-L-arginine, L-valine, L-lysine, and L-arginine joined in sequence by peptide linkages and in which the carboxy group at the C-terminus is substituted by a chloroacetyl group. It is a furin inhibitor that has antiviral activity against Chikungunya virus, Zika virus and Japanese encephalitis virus. It has a role as an antiviral agent, a peptidomimetic and an EC 3.4.21.75 (furin) inhibitor. It is a tetrapeptide and an organochlorine compound.

Biological Activity

decanoyl-rvkr-cmk is a proprotein convertase inhibitor [1].proprotein convertases (pcs) are involved in generating bioactive peptides, as well as activating several enzymes and growth factors in many important physiological events. pcs play important roles in several pathologies including viral infections and cancers. thus, pcs are promising targets for therapeutic applications [1].in pc12 cells, the pc enzyme inhibitor decanoyl-rvkr-cmk at ~ 100 μm, resulted in partial block of regulated vgf release at 48 h and a complete block at 96 h, without significant change in basal vgf release. also, decreased vgf processing was observed in cell extracts and media from decanoyl-rvkr-cmk-treated pc12 cultures [2].in k5-pace4 transgenic mice topically treated with the hyperplasiogenic phorbol ester 12-o-tetradecanoylphorbol-13-acetate (tpa), a 2-day topical treatment of decanoyl-rvkr-cmk at 300 μm, inhibited tpa-induced epidermal proliferation. when decanoyl-rvkr-cmk treatment (100 μm, q.d.) was extended for 3 weeks, decreasing numbers of ki-67-labeled cells were shown in both k5-pace4 mice epidermal basal epidermal keratinocytes and wild-type mouse epidermis [3].[1]. fugère m, day r. cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition. trends in pharmacological sciences, 2005, 26(6): 294-301.[2]. garcia a l, han s k, janssen w g, et al. a prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide vgf into the regulated secretory pathway. journal of biological chemistry, 2005, 280(50): 41595-41608.[3]. bassi d e, zhang j, cenna j, et al. proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. neoplasia, 2010, 12(7): 516-526.

storage

Store at -20°C

DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Suppliers

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150113-99-8, DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONERelated Search:


  • Decanoyl-Arg-Val-Lys-Arg-CMK·TFA
  • DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
  • DECANOYL-ARG-VAL-LYS-ARG-CMK
  • DECANOYL-RVKR-CMK
  • FURIN INHIBITOR I
  • Furin Convertase Inhibitor ( Chloromethylketone)
  • Furin Inhibitor I, Dec-RVKR-CMK
  • L-Lysinamide, N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
  • 150113-99-8
  • C34H66ClN11O5