Description
ChemicalBook > CAS DataBase List > 4-Aminotetrahydropyran

4-Aminotetrahydropyran

Description
Product Name
4-Aminotetrahydropyran
CAS No.
38041-19-9
Chemical Name
4-Aminotetrahydropyran
Synonyms
TETRAHYDRO-2H-PYRAN-4-AMINE;oxan-4-amine;TETRAHYDRO-PYRAN-4-YLAMINE;4-Aminotetrahyropyran;4-AMINOTETRAHYDROPYRAN;Tetrahydropyran-4-amine;Noe Marioni, M.D., PLLC;4-Aminotetrahydro-2H-pyran;4-Aminotetrahydropyran?New;2H-PYRAN-4-AMINE, TETRAHYDRO-
CBNumber
CB4376785
Molecular Formula
C5H11NO
Formula Weight
101.15
MOL File
38041-19-9.mol
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4-Aminotetrahydropyran Property

Boiling point:
60 °C
Density 
0.977 g/cm3 at 25 °C
refractive index 
n20/D 1.463
Flash point:
54°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
pka
9.63±0.20(Predicted)
form 
liquid
color 
Colourless
InChI
InChI=1S/C5H11NO/c6-5-1-3-7-4-2-5/h5H,1-4,6H2
InChIKey
AHVQYHFYQWKUKB-UHFFFAOYSA-N
SMILES
C1OCCC(N)C1
CAS DataBase Reference
38041-19-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
10-34-41-22-37/18
Safety Statements 
16-26-36/37/39-39
RIDADR 
2734
WGK Germany 
1
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
711357
Product name
4-Aminotetrahydropyran
Purity
97%
Packaging
1g
Price
$157
Updated
2025/07/31
TCI Chemical
Product number
A2060
Product name
Tetrahydro-2H-pyran-4-amine
Purity
min. 95.0 %
Packaging
5G
Price
$65
Updated
2025/07/31
TCI Chemical
Product number
A2060
Product name
Tetrahydro-2H-pyran-4-amine
Purity
min. 95.0 %
Packaging
25G
Price
$213
Updated
2025/07/31
TRC
Product number
A630040
Product name
4-Aminotetrahydropyran
Packaging
5g
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0025442
Product name
4-AMINOTETRAHYDROPYRAN
Purity
95.00%
Packaging
1G
Price
$163.8
Updated
2021/12/16
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4-Aminotetrahydropyran Chemical Properties,Usage,Production

Description

4-Aminotetrahydropyran contains the tetrahydropyran ring, which is the most frequently reported three-dimensional ring system in marketed drugs, and is second only to the phenyl ring when two-dimensional rings are included. It can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer. Its scaffold is very useful in the drug discovery for cancer treatment.

Application

4-Aminotetrahydropyran can be used as reactant/reagent in synthesis of aminothiazole compounds for use in treatment of cancer.

Synthesis

61128-73-2

38041-19-9

General procedure for the synthesis of 4-aminotetrahydropyran from dihydro-2H-pyran-4(3H)-one oxime: Raney Ni (10%) was added to a stirred solution of compound 2.2 (1.0 g, 8.7 mmol) in methanol (50 mL) and the resulting mixture was stirred for 5 hr at room temperature in a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the catalyst was removed by filtration and the methanol solvent in the filtrate was concentrated in vacuum to afford the target product 4-aminotetrahydropyran (Compound 2.3, 0.5 g, 57% yield).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2210 - 2221
[2] Patent: US2009/82423, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: US5707989, 1998, A
[4] Patent: US5821240, 1998, A
[5] Patent: US5977102, 1999, A

4-Aminotetrahydropyran Preparation Products And Raw materials

Raw materials

Ammonium formate Tetrahydro-4H-pyran-4-one Palladium

Preparation Products

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View Lastest Price from 4-Aminotetrahydropyran manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Aminotetrahydropyran 38041-19-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Aminotetrahydropyran 38041-19-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-11
Henan Aochuang Chemical Co.,Ltd.
Product
4-Aminotetrahydropyran 38041-19-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19

38041-19-9, 4-AminotetrahydropyranRelated Search:

Tetrahydro-2H-pyran-4-carboxylic acid Tetrahydropyran Centchroman Tetrahydro-4H-pyran-4-one AMINOACETONITRILE HYDROGEN SULFATE 4-AMINOTETRAHYDROPYRAN, HCL,4-AMINOTETRAHYDROPYRAN HYDROCHLORIDE,4-AMINOTETRAHYDROPYRAN HYDROCHLORIDE (TETRAHYDRO-2H-PYRAN-4-AMINE HYDROCHLORIDE) tetrahydropyran-4,4-dicarboxylic acid Tetrahydropyran-4-carbaldehyde Tetrahydropyran-4-boronic acid pinacol ester TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID METHYLAMIDE TETRAHYDRO-PYRAN-3-YLAMINE HYDROCHLORIDE 4,4,5,5-Tetramethyl-2-(tetrahydro-2H-pyran-3-yl)-1,3,2-dioxaborolane Gentamicin KANAMYCIN MEPARTRICIN Geneticin Nystatin picromycin

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