ChemicalBook > CAS DataBase List > 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one

1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one

Product Name
1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one
CAS No.
670270-31-2
Chemical Name
1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one
Synonyms
IU1 47;IU1-47, 10 mM in DMSO;IU1-47 | Deubiquitinase;inhibit,IU1 47,Deubiquitinase,IU-1-47,IU1-47,DUBs,Inhibitor,IU147;1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone;Ethanone, 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-;1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one
CBNumber
CB43840421
Molecular Formula
C19H23ClN2O
Formula Weight
330.85
MOL File
670270-31-2.mol
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1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one Property

Boiling point:
475.1±45.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 16.67 mg/mL (50.39 mM; Need ultrasonic)
form 
A solid
pka
7.08±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6443
Product name
IU1-47
Purity
≥98%(HPLC)
Packaging
10
Price
$174
Updated
2021/12/16
Tocris
Product number
6443
Product name
IU1-47
Purity
≥98%(HPLC)
Packaging
50
Price
$731
Updated
2021/12/16
Axon Medchem
Product number
Axon3426
Product name
IU1-47
Purity
99%
Packaging
5mg
Price
$88
Updated
2021/12/16
Biosynth Carbosynth
Product number
BI167097
Product name
IU1 47
Packaging
10mg
Price
$125
Updated
2021/12/16
ChemScene
Product number
CS-0083044
Product name
IU1-47
Purity
99.76%
Packaging
10mg
Price
$290
Updated
2021/12/16
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1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one Chemical Properties,Usage,Production

Uses

IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons[1].

Biological Activity

IU1-47 is a potent and selective inhibitor of the deubiquitinating enzyme UPS14. IU1-47 enhances protein degradation including human wild-type and pathological Tau forms in neurons.

storage

Store at -20°C

References

[1] Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225. DOI:10.1074/jbc.M117.815126

1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one Suppliers

Canada 1 China 39 Ukraine 1 United Kingdom 2 United States 4 USA 1 Global 48
OTAVA chemicals
Tel
--
Fax
--
Email
north.america@otavachemicals.com
Country
Ukraine
ProdList
6495
Advantage
72

670270-31-2, 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-oneRelated Search:


  • 1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one
  • IU1 47
  • 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
  • Ethanone, 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-
  • inhibit,IU1 47,Deubiquitinase,IU-1-47,IU1-47,DUBs,Inhibitor,IU147
  • IU1-47 | Deubiquitinase
  • IU1-47, 10 mM in DMSO
  • 670270-31-2