5-Bromo-3-iodo-1H-indazole
- Product Name
- 5-Bromo-3-iodo-1H-indazole
- CAS No.
- 459133-66-5
- Chemical Name
- 5-Bromo-3-iodo-1H-indazole
- Synonyms
- 5-BROMO-3-IODOINDAZOLE;5-BROMO-3-IODO (1H)INDAZOLE;1H-Indazole, 5-broMo-3-iodo--;1H-Indazole, 5-broMo-3-iodo--3
- CBNumber
- CB4389097
- Molecular Formula
- C7H4BrIN2
- Formula Weight
- 322.93
- MOL File
- 459133-66-5.mol
5-Bromo-3-iodo-1H-indazole Property
- Melting point:
- 196 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 413.1±25.0 °C(Predicted)
- Density
- 2.421±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.78±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C7H4BrIN2/c8-4-1-2-6-5(3-4)7(9)11-10-6/h1-3H,(H,10,11)
- InChIKey
- IBFAYUXCRDDBRD-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Br)C=C2)C(I)=N1
Safety
- RIDADR
- UN2811
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- B688923
- Product name
- 5-Bromo-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR60116
- Product name
- 5-Bromo-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 3H32-S-01
- Product name
- 5-Bromo-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FB54424
- Product name
- 5-Bromo-3-iodo indazole
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR60116
- Product name
- 5-Bromo-3-iodo-1H-indazole
- Packaging
- 250mg
- Price
- $28
- Updated
- 2021/12/16
5-Bromo-3-iodo-1H-indazole Chemical Properties,Usage,Production
Uses
5-Bromo-3-iodo-1H-indazole is important chemical intermediate.
Synthesis
53857-57-1
459133-66-5
General procedure for the synthesis of 5-bromo-3-iodo-1H-indazole from 5-bromo-1H-indazole: To a solution of 5-bromo-1H-indazole (5.0 g, 25.4 mmol, 1.0 eq.) in anhydrous DMF (15.0 mL) was added sequentially, protected by nitrogen, KOH (4.3 g, 76.1 mmol, 3.0 eq.) and iodine (12.9 g, 50.75 mmol, 2.0 equiv). The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction solution was diluted with ice water and then extracted with ethyl acetate (50 mL x 2). The organic layers were combined, washed sequentially with aqueous Na2S2O3 and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford the crude product 5-bromo-3-iodo-1H-indazole (8.0 g, 97.9% yield), which could be used for the next reaction without further purification.
References
[1] Molecules, 2018, vol. 23, # 8,
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2361 - 2372
[3] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00213
[4] Synthesis, 2006, # 20, p. 3506 - 3514
[5] Letters in Drug Design and Discovery, 2013, vol. 10, # 7, p. 625 - 631
5-Bromo-3-iodo-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-3-iodo-1H-indazole manufacturers
- Product
- 5-BROMO-3-IODO (1H)INDAZOLE 459133-66-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-BROMO-3-IODO (1H)INDAZOLE 459133-66-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-BROMO-3-IODO (1H)INDAZOLE 459133-66-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02