ChemicalBook > CAS DataBase List > O-304

O-304

Product Name
O-304
CAS No.
1261289-04-6
Chemical Name
O-304
Synonyms
O-304;0 304;CS-2682;O-304;0 304;O-304 (O304);O-304 1261289-04-6;O-304, 10 mM in DMSO;O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304;4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide;Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-
CBNumber
CB43960103
Molecular Formula
C16H11Cl2N3O2S
Formula Weight
380.25
MOL File
1261289-04-6.mol
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O-304 Property

Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml; Ethanol: slightly soluble
form 
A crystalline solid
pka
7.81±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)
InChIKey
WEDWLYRQKUTOAX-UHFFFAOYSA-N
SMILES
C(NC1SN(CC2=CC=C(Cl)C=C2)C(=O)N=1)(=O)C1=CC=C(Cl)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26186
Product name
O-304
Packaging
1mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
26186
Product name
O-304
Packaging
5mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
26186
Product name
O-304
Packaging
10mg
Price
$448
Updated
2024/03/01
ChemScene
Product number
CS-0044210
Product name
O-304
Purity
99.72%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0044210
Product name
O-304
Purity
99.72%
Packaging
10mg
Price
$280
Updated
2021/12/16
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O-304 Chemical Properties,Usage,Production

Uses

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

in vivo

O-304 increases glucose uptake in skeletal muscle, reduces β cell stress, and promotes β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin[2].

References

[1] Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes).

O-304 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from O-304 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
O-304 1261289-04-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2025-08-31
Xi an Biohorlden Industry Trade Co Ltd
Product
O-304 1261289-04-6
Price
US $0.00-0.00/g
Min. Order
100g
Purity
99%
Supply Ability
20kg
Release date
2025-07-09

1261289-04-6, O-304Related Search:


  • O-304
  • O-304 1261289-04-6
  • 4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide
  • CS-2682
  • 0 304
  • O-304;0 304
  • Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-
  • O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304
  • O-304, 10 mM in DMSO
  • O-304 (O304)
  • 1261289-04-6