ChemicalBook > CAS DataBase List > Losartan carboxylic acid

Losartan carboxylic acid

Product Name
Losartan carboxylic acid
CAS No.
124750-92-1
Chemical Name
Losartan carboxylic acid
Synonyms
exp3174;Losartan Carboxylic Acid;e-3174;LOSARTAN CARBOXY ACID;EXP 317;l-158641;AKOS 91941;ALSTint-A07;Losartan acid;E-3174, EXP-3174
CBNumber
CB4399601
Molecular Formula
C22H21ClN6O2
Formula Weight
436.89
MOL File
124750-92-1.mol
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Losartan carboxylic acid Property

Melting point:
130-132°C
Boiling point:
707.8±70.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Dimethylformamide, Dimethyl Sulfoxide, Methanol
form 
Solid
pka
0.79±0.50(Predicted)
color 
Light-Yellow
InChI
InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
InChIKey
ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES
C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1
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Safety

Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H362May cause harm to breast-fed children

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB01354
Product name
Losartan carboxylic acid
Purity
≥95% (HPLC)
Packaging
5MG
Price
$75.9
Updated
2023/01/07
Sigma-Aldrich
Product number
SMB01354
Product name
Losartan carboxylic acid
Purity
≥95% (HPLC)
Packaging
25MG
Price
$303
Updated
2023/01/07
Cayman Chemical
Product number
15957
Product name
Losartan Carboxylic Acid
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
15957
Product name
Losartan Carboxylic Acid
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
15957
Product name
Losartan Carboxylic Acid
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
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Losartan carboxylic acid Chemical Properties,Usage,Production

Description

Losartan carboxylic acid is a physiologically active metabolite of losartan , produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation in vitro.

Chemical Properties

Light-Yellow Solid

Uses

Losartan carboxylic acid is used as a metabolite of Losartan.

Definition

ChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.

in vitro

e-3174 potently blocked the specific binding of [125i]-aii to vsmc isolated from rat aorta. e-3174 was able to dampen the platelet-derived growth factor-induced increase in cell dna synthesis and protein, which led to the blockade of the aii-induced increase in cell protein [1].

in vivo

rats were administrated e-3174 intravenously at a dose of l.0 mg/kg. after 6 hours, e-3174 markedly attenuated the cardiovascular effects of aii in rats. e-3174 induced a progressive fall in mean arterial pressure and a marked increase in renal flow only [2].

storage

Store at -20°C

References

[1]. li, x. & widdop, r. angiotensin type i receptor antagonists cy-11974 and exp 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats. clinical science, 1996; 91(2): 147-154.
[2]. sachinidis, a., ko, y., weisser, p., zu bricbkwedde, m., dsing, r., & christian, r. et al. exp3174, a metabolite of losartan (mk954, dup753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells. journal of hypertension. 1993; 11(2): 155-162.

Losartan carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Losartan
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Losartan carboxylic acid Suppliers

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View Lastest Price from Losartan carboxylic acid manufacturers

Hebei Lingding Biotechnology Co., Ltd.
Product
Losartan Carboxylic Acid 124750-92-1
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-09-01
Shaanxi Dideu Medichem Co. Ltd
Product
Losartan Carboxylic Acid 124750-92-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09
Career Henan Chemical Co
Product
2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID 124750-92-1
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
200kgs
Release date
2020-01-17

124750-92-1, Losartan carboxylic acidRelated Search:

Losartan potassium Ethyl acetate Metoprolol Candesartan cilexetil Valsartan Irbesartan Losartan Trityl losartan 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]-methyl-1H-imidazole-5-carboxylic acid (LOSARTAN METABOLITE). AKOS 91707 AKOS 91711 Losartan carboxylic acid

  • LOSARTAN CARBOXY ACID
  • AKOS 91941
  • 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
  • ’-biphenyl)-4-yl)methyl)-
  • 1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2’-(14-tetrazol-5-yl)(1,1
  • E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174
  • 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
  • E-3174, EXP-3174
  • 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid
  • 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid
  • 1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • ALSTint-A07
  • 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
  • 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formic acid
  • LOSARTAN,2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
  • Losartan Impurity 14
  • 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicAcid
  • EXP 317
  • Losartan Carboxylic Acid Discontinued see product # L470510
  • Losartan Carboxylic Acid
  • e-3174
  • exp3174
  • l-158641
  • EXP 3174 (LOSARTAN CARBOXYLIC ACID)
  • 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-carboxylic acid
  • 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic acid
  • 2-Butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid
  • 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
  • Losartan Carboxylic Acid NEW CATALOGUE NUMBER: see product # L470510
  • Losartan acid
  • Losartan carboxylic acid, >=98%
  • 1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
  • 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1
  • E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1;1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID
  • Losartan Carboxylic Acid USP/EP/BP
  • 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID USP/EP/BP
  • Losartan Carboxylic Acid (Losartan Carboxylate)
  • Losartan Carboxylic acid Impurity
  • Losartan carboxylic acidQ: What is Losartan carboxylic acid Q: What is the CAS Number of Losartan carboxylic acid Q: What is the storage condition of Losartan carboxylic acid Q: What are the applications of Losartan carboxylic acid
  • 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Losartan Carboxylic Acid)
  • 124750-92-1
  • C22H21ClN6O2
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Heterocycles