DIISOPROPYL (ETHOXYCARBONYLMETHYL)PHOSPHONATE Property

Boiling point:

142-143 °C11 mm Hg(lit.)

Density 

1.06 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.427(lit.)

Flash point:

>230 °F

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DIISOPROPYL (ETHOXYCARBONYLMETHYL)PHOSPHONATE Chemical Properties,Usage,Production

Uses

Reactant for:

• Preparation of spiroimine ring fragment of spirolides via stereoselective intermolecular Diels-Alder and aza-Wittig cyclization
• Katsuki-Sharpless epoxidation reaction
• Preparation of nine-membered diallylic sulfonamides as chiral building blocks
• Alpha-phosphono lactams for subsequent Wadsworth-Emmons olefination, and Suzuki coupling reactions to yield diverse pyrrolidinone compounds
• Synthesis of galactosylceramide analog that induces Th1-biased responses in human (NKT) cells
• Stereoselective total synthesis of the ionophore antibiotic zincophorin (M144255)