Physical and chemical properties Toxicity Mode of action Target plants Application How to use Preparation Methods
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Clethodim

Physical and chemical properties Toxicity Mode of action Target plants Application How to use Preparation Methods
Product Name
Clethodim
CAS No.
99129-21-2
Chemical Name
Clethodim
Synonyms
2-[1-[[[(2E)-3-Chloro-2-propen-1-yl]oxy]iMino]propyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one;Ogive;re45601;ethodim;PRISM(R);RH 45601;SELECT(R);CLETHODIM;Centurion;Volunteer
CBNumber
CB4404330
Molecular Formula
C17H26ClNO3S
Formula Weight
359.91
MOL File
99129-21-2.mol
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Clethodim Property

Melting point:
<25 °C
Boiling point:
472.6±55.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
0-6°C
solubility 
Chloroform (Sparingly, Sonicated), Ethyl Acetate (Slightly), Methanol (Sparingly
pka
4.28±0.25(Predicted)
form 
Liquid
color 
Light Yellow to Dark Yellow
Stability:
Hygroscopic
CAS DataBase Reference
99129-21-2(CAS DataBase Reference)
EPA Substance Registry System
Clethodim (99129-21-2)
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Safety

Safety Statements 
22-24/25
RIDADR 
UN3082 (environmentally haz- ardous substances, liquid, n. o. s.)
WGK Germany 
3
HS Code 
29309090
Hazardous Substances Data
99129-21-2(Hazardous Substances Data)
Toxicity
LD50 in male, female rats (mg/kg): 1630, 1360 orally; LC50 in trout: 56 mg/l; 8 day feeding in quail: > 6000 ppm (Kincade)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
34190
Product name
Clethodim
Purity
PESTANAL
Packaging
50mg
Price
$205
Updated
2024/03/01
TRC
Product number
C573250
Product name
Clethodim
Packaging
100mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
O401
Product name
Clethodim,tech.
Packaging
1g
Price
$98
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20477
Product name
Clethodim
Packaging
100mg
Price
$219
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PST0000262
Product name
CLETHODIM
Purity
95.00%
Packaging
100MG
Price
$716.1
Updated
2021/12/16
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Clethodim Chemical Properties,Usage,Production

Physical and chemical properties

The original medicine is amber transparent liquid with relative density 1.14 (20 ℃) and vapor pressure <1 × 10-2mPa (20 ℃). It is soluble in most organic solvents, stable under ultraviolet light, but unstable at extreme pH.

Toxicity

The acute oral toxicity of original medicine LD50 in rats was 1360 mg / kg (female) , 1630 mg / kg (male). The acute dermal toxicity LD(50) in rabbits was more than 5g/kg. The acute inhalation LC50 in rats (4 hours) is more than 4.6mg/L . No effect dose during Feeding test: rat 16mg / kg • d, mice 30mg / kg • d. ADI by humans is 0.01 mg / kg. The acute oral toxicity LD50 in quails is more than 2g / kg. The acute inhalation LC50 (8 days) in wild ducks and quails is more than 6g / kg. The LC50 in daphnias is > 120mg / L. The LD50 in insects is 454 mg / kg. The LC50 in blue gill fish (96 hours)is > 120mg / L, The LC50 in rainbow trout is 5056mg / L. The LD50 in bees is > 100μg per bee.

Mode of action

It is a selective, systemic post-emergence herbicide which can be rapidly absorbed by plant leaves and conducted to roots and growing points to inhibit the biosynthesis of plant branched-chain fatty acids. The target weeds then grow slowly and lose competitiveness with seedling tissue early yellowing and followed by the remaining leaves wilting. Finally they will die.

Target plants

Suitable for broad-leaf plants. All tested plants of non-grass family were highly resistant to RE-45601 throughout the entire growth and development period, even applied with 2 kg ai / hm2 (8-20 times higher than herbicides) plus vegetable oil 2.341 / hm2, the situation still remains the same.
Soybeans and cotton can be sowed immediately after application of RE-45601. Other crops can be sowed 4 months after application of RE-45601 at a dose of 1.12 kg ai / hm2 or less.

Application

Applicable to annual and perennial grass weeds and many Field maize cereals withbroad-leaf. (1) annual species (84-140 g ai / hm2): Kusamiligus ostreatus, wild oats, wool millet, brachiopod, mangrove, black brome, ryegrass, gall grass, French foxtail, hemostatic horse, Golden Foxtail, Crabgrass, Setaria viridis, Echinochloa crus-galli, Dichromatic Sorghum, Barnyardgrass, Wheat, Lemna, Corn; Barley , (2) Arabian sorghum of perennial species (84-140 g ai / hm2); (3) Perennial species (140 ~ 280g ai / hm2) bermudagrass, creeping wild wheat.
It’s not or slightly active against broad-leaf weeds or Carex. The crops of grass family such as barley, corn, oats, rice, sorghum and wheat are all susceptible to RE-45601. Therefore the autogenesis plants in the filed where crops of non-grass family can be controlled with RE-45601.

How to use

RE-45601 gets the best control effect during the period when grass weeds grow vigorously. Drought, low temperature (below 15 ° C) and other unfavorable factors sometimes reduce the activity of RE-45601. For annual weeds of grass family, it should be applied during the 3 to 5 leaf stage. For perennial weeds of grass family, herbicide should be applied after weeds tillering; increase of the dose or number of applications is needed for non- appropriate period for spraying. If an even distribution of droplets can be applied, low spray volume (ie 50L / hm2)is more effective than the high spray volume (180 ~ 280L / hm2). The biological activity can be improved by adding vegetable oil 2.34L / hm2. The active ingredient in RE-45601 is absorbed by plants within 1 hour, so the rainfall after application will not reduce the effect.

Preparation Methods

5-alkylcyclohexanedione-3-carboxylate is produced by the condensation and cyclization of the corresponding ketene and diethyl malonatein the presence of sodium hydroxide, then compound(Ⅰ) is obtained by hydrolysis and decarboxylation, followed by its reaction with propionyl chloride to form 3-propionyloxy-5-alkylcyclohexenone which is soluble in methylene chloride . then has isomerization reaction in the presence of aluminum trichloride and finally reacts with H2NOCH2CH = CHCl to produce,clethodim. The response equation is as follows:

Chemical Properties

Clear Yellow Oil

Uses

Systemic graminicide. Post-emergent herbicide.

Definition

ChEBI: Clethodim is an oxime O-ether resulting from the formal conversion ot the acyclic keto group of 5-[2-(ethylsulfanyl)propyl]-3-hydroxy-2-propionylcyclohex-2-en-1-one to the corresponding oxime with subsequent O-alkylation of the oxime by an (E)-3-chloroallyl group. It is used as a selective postemergence herbicide for the control of annual and perennial grasses in numerous crops, including alfalfa, celery, clover, conifers, cotton, cranberries, garlic, onions, ornamentals, peanuts, soybeans, strawberries, sugarbeet, sunflowers, and vegetables; the (-)-enantiomer has been reported to be more active than the (+)-enantiomer. It has a role as a herbicide and an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor. It is an organic sulfide, a cyclic ketone, an organochlorine compound, an oxime O-ether, a beta-diketone and an enol.

Agricultural Uses

Herbicide: Not approved for use in EU countries. A selective post-emergence herbicide used to control annual and perennial grasses to a range of crops including cotton, flax, peanuts, soybeans, sugarbeets, potatoes, alfalfa, sunflowers and most vegetables.

Trade name

CLETODIME®; PRISM®; RE 45601; SELECT®

Clethodim Preparation Products And Raw materials

Raw materials

Preparation Products

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Clethodim Suppliers

Jiangsu Agrochem Laboratory
Tel
0519-5109160
Fax
0086-519-85108116
Email
sales@agrochemlab.com
Country
China
ProdList
180
Advantage
54
Hubei wei shi reagent group ltd., company
Tel
027-59102966 18717199209
Fax
027-59379337
Email
2853877583@qq.com
Country
China
ProdList
3522
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Rudong Zhongyi Chemical Co., Ltd
Tel
13306234115
Fax
+86-0513-84819568
Email
jszyzj@zhongyichem.com
Country
China
ProdList
36
Advantage
60
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
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View Lastest Price from Clethodim manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
Clethodim 99129-21-2
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
10 tons
Release date
2024-06-13
qingdao trust agri chemical co.,ltd
Product
clethodim 99129-21-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20tons
Release date
2024-07-24
Qiuxian Baitai New Material Co., LTD
Product
Clethodim 99129-21-2
Price
US $3.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-11-04

99129-21-2, ClethodimRelated Search:


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  • SELECT(R)
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