ChemicalBook > CAS DataBase List > 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
- Product Name
- 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
- CAS No.
- 221243-82-9
- Chemical Name
- 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
- Synonyms
- CS-2001;1-NA-PP1;1-Naphthyl PP1;1-NAPHTHYL PP1(1-NA-PP 1);1-Naphthyl PP1, PKD inhibitor;4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE;1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-
- CBNumber
- CB4413972
- Molecular Formula
- C19H19N5
- Formula Weight
- 317.39
- MOL File
- 221243-82-9.mol
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4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Property
- Melting point:
- 219-222°C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 10954
- Product name
- 1-NA-PP1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $23
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10954
- Product name
- 1-NA-PP1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10954
- Product name
- 1-NA-PP1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10954
- Product name
- 1-NA-PP1
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $717
- Updated
- 2024/03/01
Tocris
- Product number
- 3063
- Product name
- 1-NaphthylPP1
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $1184
- Updated
- 2021/12/16
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4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
White Cyrstalline Solid
Uses
A highly potent (IC50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase
Definition
ChEBI: 1-NA-PP1 is a pyrazolopyrimidine. It has a role as a tyrosine kinase inhibitor.
Biological Activity
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC 50 values are 1.0, 0.6, 0.6, 18 and 22 μ M for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC 50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Synthesis
Add 3-iodo-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine into a 250mL three-necked flask, dissolve in 300ml 10% Na2CO3, add 150ml dioxane, After cooling to 0 °C, Fmoc boronate was dissolved in 225 ml of acetone and added dropwise to the system. Stir at room temperature for 3h, pour into 1000ml of water, extract twice with ether, cool and adjust pH to about 2 with concentrated hydrochloric acid, extract with ethyl acetate (3×100ml), dry over MgSO4, evaporate the solvent, and rotate under reduced pressure. The crude product is subjected to silica gel column chromatography (V methanol: V dichloromethane=1:35) to give 4-amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-D] pyrimidine as a white crystal-like solid .
storage
+4°C
4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE manufacturers
Career Henan Chemical Co
- Product
- 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE 221243-82-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13
221243-82-9, 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINERelated Search:
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PP1
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4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE