1422253-38-0

Product Name: 1422253-38-0
CAS No.: 1422253-38-0
Chemical Name: 1422253-38-0
Synonyms: C-82 prodrug;ICG001 analog;ICG-001 analog;ICG 001 analog;FOSCENVIVINT (PRI-724);PRI-724, 10 mM in DMSO;C-82 prodrug|||Foscenvivint;4-(((6S,9S,9AS)-1-(BENZYLCARBAMOYL)-2,9-DIMETHYL-4,7-DIOXO-8- (QUINOLIN-8-YLMETHYL)OCTAHYDRO-2H-PYRA;4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate;4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8- (quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl) methyl)phenyl dihydrogen phosphate
CBNumber: CB44187671
Molecular Formula: C33H35N6O7P
Formula Weight: 658.64
MOL File: 1422253-38-0.mol

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1422253-38-0 Property

Density: 1.48±0.1 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
pka: 1.26±0.30(Predicted)
form: Solid
color: White to off-white
InChIKey: VHOZWHQPEJGPCC-AZXNYEMZSA-N
SMILES: N1(C)CC(=O)N2[C@@H](CC3=CC=C(OP(O)(O)=O)C=C3)C(=O)N(CC3=C4C(=CC=C3)C=CC=N4)[C@@H](C)[C@]2([H])N1C(NCC1=CC=CC=C1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0042484
Product name: PRI-724
Purity: 98.31%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0042484
Product name: PRI-724
Purity: 98.31%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0042484
Product name: PRI-724
Purity: 98.31%
Packaging: 25mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-0042484
Product name: PRI-724
Purity: 98.31%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-0042484
Product name: PRI-724
Purity: 98.31%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

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1422253-38-0 Chemical Properties,Usage,Production

Uses

PRI 724 is a studied as a prospect for safely and effectively targeting catenin coactivator antagonism interactions to eliminate cancer stem cell population in human cancer.

in vivo

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs^[1].

References

[1] Y. OSAWA. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice[J]. EBioMedicine, 2015, 58 1: 1751-1758. DOI: 10.1016/j.ebiom.2015.10.010
[2] ZEYUAN YU. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination[J]. Oncogene, 2020, 40 5: 1027-1042. DOI: 10.1038/s41388-020-01572-w
[3] ROBERT KLESZCZ Jarosław P. The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells.[J]. International Journal of Molecular Sciences, 2022, 23 3. DOI: 10.3390/ijms23031248
[4] M MAVIGNER. Pharmacological Modulation of the Wnt/β-Catenin Pathway Inhibits Proliferation and Promotes Differentiation of Long-Lived Memory CD4+ T Cells in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.[J]. Journal of Virology, 2019, 94 1. DOI: 10.1128/jvi.01094-19

1422253-38-0 Preparation Products And Raw materials

Raw materials

Preparation Products

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1422253-38-0 Suppliers

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1422253-38-0, 1422253-38-0Related Search:

4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8- (quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl) methyl)phenyl dihydrogen phosphate

4-(((6S,9S,9AS)-1-(BENZYLCARBAMOYL)-2,9-DIMETHYL-4,7-DIOXO-8- (QUINOLIN-8-YLMETHYL)OCTAHYDRO-2H-PYRA

2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, hexahydro-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-8-(8-quinolinylmethyl)-, (6S,9S,9aS)-

4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate

4-[[(6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] dihydrogen phosphate

FOSCENVIVINT (PRI-724)

C-82 prodrug

ICG 001 analog

ICG001 analog

ICG-001 analog

C-82 prodrug|||Foscenvivint

PRI-724, 10 mM in DMSO

1422253-38-0