ChemicalBook > CAS DataBase List > 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE

4',6'-DIMETHOXY-2'-HYDROXYCHALCONE

Product Name
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
CAS No.
1775-97-9
Chemical Name
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
Synonyms
FlavoringB;Flavokavin B;FLAVOKAWIN B;FLAVOKAWAIN B;Flavokavain B;FLAVOKAVAIN B(P);Flavokawain B-RM;CARDAMONIN-4'-METHYL ETHER;4',6'-DIMETHOXY-2'-HYDROXYCHALCONE;2'-Hydroxy-4',6'-Dimethoxychalcone
CBNumber
CB4430922
Molecular Formula
C17H16O4
Formula Weight
284.31
MOL File
1775-97-9.mol
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4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Property

Melting point:
85-87°C
Boiling point:
500.1±50.0 °C(Predicted)
Density 
1.203±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
6.84±0.40(Predicted)
form 
Solid
color 
Yellow to Dark Yellow
LogP
4.206 (est)
CAS DataBase Reference
1775-97-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19652
Product name
Flavokawain B
Purity
≥98%
Packaging
500μg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
19652
Product name
Flavokawain B
Purity
≥98%
Packaging
1mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
19652
Product name
Flavokawain B
Purity
≥98%
Packaging
5mg
Price
$253
Updated
2024/03/01
Cayman Chemical
Product number
19652
Product name
Flavokawain B
Purity
≥98%
Packaging
10mg
Price
$404
Updated
2024/03/01
Usbiological
Product number
300275
Product name
Flavokawain B
Packaging
20mg
Price
$552
Updated
2021/12/16
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4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Chemical Properties,Usage,Production

Description

Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 μM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 μM, respectively).

Uses

Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models. ?Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.

Definition

ChEBI: Flavokawain B is a member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities. It has a role as a metabolite, an antileishmanial agent, an anti-inflammatory agent, an apoptosis inducer and an antineoplastic agent. It is a member of chalcones, a dimethoxybenzene and a member of phenols. It is functionally related to a trans-chalcone.

4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4',6'-DIMETHOXY-2'-HYDROXYCHALCONE Suppliers

China 106 France 1 Germany 2 India 4 United Kingdom 10 United States 15 USA 1 Global 139
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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60
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
BEIJING TDVINO TECHNOLOGY CO.,LTD
Tel
010-56371379
Fax
010-56371379
Country
China
ProdList
99
Advantage
55
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
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Germany
ProdList
4705
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70
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Nanjing Endesa Bio-tech Co., Ltd.
Tel
025-58862853 18915922038
Fax
+86-025-58862853
Email
sales@endesachem.com
Country
China
ProdList
591
Advantage
58
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
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View Lastest Price from 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Flavokawain B 1775-97-9
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-04-26
Career Henan Chemical Co
Product
4',6'-DIMETHOXY-2'-HYDROXYCHALCONE 1775-97-9
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

1775-97-9, 4',6'-DIMETHOXY-2'-HYDROXYCHALCONERelated Search:

EUPATORIN-5-METHYL ETHER 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE 3',4',5,7-TETRAMETHOXYFLAVONE SCUTELLAREIN TETRAMETHYL ETHER Hesperidin methylchalcone 5,7-DIMETHOXYFLAVONE 3',4',5',5,6,7-HEXAMETHOXYFLAVONE 2'-HYDROXY-4,4',6'-TRIMETHOXYCHALCONE 3',4',5',5,7-PENTAMETHOXYFLAVONE 5,6,7-TRIMETHOXYFLAVONE 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE Tangeretin DIMETHOXY-2'-HYDROXYCHALCONE, 2,3-,2,3-DIMETHOXY-2'-HYDROXYCHALCONE 2-HYDROXYCHALCONE 2-Hydroxychalcone 2'-Hydroxychalcone CARDAMONIN 4',5,7-TRIMETHOXYFLAVONE

  • CARDAMONIN-4'-METHYL ETHER
  • FLAVOKAWAIN B
  • FLAVOKAWIN B
  • DIMETHOXY-2'-HYDROXYCHALCONE, 4',6'-
  • (E)-1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPENONE
  • 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
  • 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one)
  • (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-
  • FLAVOKAVAIN B(P)
  • Flavokavin B
  • (E)-2'-Hydroxy-4',6'-dimethoxychalcone
  • Flavokavain B
  • (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
  • (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
  • 2'-Hydroxy-4',6'-Dimethoxychalcone
  • 2-Propen-1-one,1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-
  • 4',6'-Dimethoxy-2'-hydroxychalcone (Flavokawain B)
  • FlavoringB
  • 4',6'-DIMETHOXY-2'-HYDROXYCHALCONE
  • Flavokawain B-RM
  • 1775-97-9
  • Chalcones
  • Plant Oils, Toxins, Phenolic Acids & Derivatives