CHLOROMETHYL BENZOATE
- Product Name
- CHLOROMETHYL BENZOATE
- CAS No.
- 5335-05-7
- Chemical Name
- CHLOROMETHYL BENZOATE
- Synonyms
- NSC 2876;CHLOROMETHYL BENZOATE;Chloromethanol benzoate;Benzoyloxymethyl chloride;Methanol,1-chloro-,benzoate;Benzoic acid chlroMethyl ester;Methanol, 1-chloro-, 1-benzoate;Benzoic acid chloromethyl ester
- CBNumber
- CB4431424
- Molecular Formula
- C8H7ClO2
- Formula Weight
- 170.59
- MOL File
- 5335-05-7.mol
CHLOROMETHYL BENZOATE Property
- Boiling point:
- 114-115 °C(Press: 8 Torr)
- Density
- 1.229±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Colourless
- EPA Substance Registry System
- Chloromethyl benzoate (5335-05-7)
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C428290
- Product name
- Chloromethylbenzoate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2623-5-02
- Product name
- Chloromethyl benzoate
- Purity
- 97%
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J54618
- Product name
- Chloromethylbenzoate
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 2623-5-02
- Product name
- Chloromethyl benzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- X7024
- Product name
- Chloromethylbenzoate
- Packaging
- 10g
- Price
- $161
- Updated
- 2021/12/16
CHLOROMETHYL BENZOATE Chemical Properties,Usage,Production
Synthesis
50-00-0
98-88-4
5335-05-7
The general procedure for the synthesis of chloromethyl benzoate from formaldehyde and benzoyl chloride was as follows: paraformaldehyde (4.5 g) was mixed with a catalytic amount of zinc chloride at 0°C. Subsequently, benzoyl chloride (0.142 mol, 20 g) was added slowly and dropwise over a period of 1 hour. The reaction mixture was gradually warmed up to room temperature, then heated to 55 °C and maintained at this temperature for 10 h of reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, silica gel plate, unfolding agent ratio 5:95 ethyl acetate/hexane). If the TLC showed that there were still raw materials unreacted, 1 g of paraformaldehyde was added additionally. After continuing the reaction with stirring at 55 °C for 10 h, the reaction mixture was cooled and purified by fast column chromatography (500 g silica gel, eluent a solvent mixture of 2% ethyl acetate and 98% hexane). The solvent was evaporated under vacuum, taking care that the temperature of the water bath of the rotary evaporator did not exceed 35 °C to avoid loss of product due to low boiling point. Finally 11.82 g (49% yield) of the target product chloromethyl benzoate was obtained as a clear oil. The mass spectrum (electrospray positive ion mode, ES+) showed m/e 171 (M+H).
References
[1] Russian Journal of Organic Chemistry, 2013, vol. 49, # 2, p. 198 - 203
[2] Zh. Org. Khim., 2013, vol. 49, # 2, p. 210 - 214,5
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 771 - 778
[4] Synthetic Communications, 1995, vol. 25, # 18, p. 2739 - 2749
[5] Patent: WO2004/92189, 2004, A1. Location in patent: Page 26
CHLOROMETHYL BENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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