ZIMELIDINE DIHYDROCHLORIDE

Product Name: ZIMELIDINE DIHYDROCHLORIDE
CAS No.: 56775-88-3
Chemical Name: ZIMELIDINE DIHYDROCHLORIDE
Synonyms: Zelmid;D015031;H-102/09;Zimeldine;Zimelidine;cis-h102/09;cis-H 102/09;cis-Zimelidine;(Z)-Zimelidine;Hydrochloride, zimeldine
CBNumber: CB4431888
Molecular Formula: C16H17BrN2
Formula Weight: 317.22
MOL File: 56775-88-3.mol

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ZIMELIDINE DIHYDROCHLORIDE Property

Melting point:: 193°C
Density: 1.4039 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Desiccate at RT
solubility: 0.1 M HCl: 45 mg/mL
form: solid
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
Hazardous Substances Data: 56775-88-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 257163
Product name: Zimelidine dihydrochloride
Packaging: 10mg
Price: $310
Updated: 2021/12/16

Usbiological

Product number: Z0445
Product name: Zimeldine
Packaging: 5mg
Price: $460
Updated: 2021/12/16

Usbiological

Product number: 292107
Product name: Zimeldine
Packaging: 2mg
Price: $460
Updated: 2021/12/16

TRC

Product number: Z435000
Product name: Zimeldine
Packaging: 50mg
Price: $1455
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FZ28762
Product name: Zimeldine
Packaging: 1mg
Price: $160
Updated: 2021/12/16

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ZIMELIDINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Tan Oil

Originator

Normud ,Astra ,W. Germany ,1981

Uses

Zimeldine is a serotonin uptake inhibitor. Antidepressant.

Uses

Zimelidine Dihydrochloride, is a selective 5-HT uptake inhibitor. It modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant.

Definition

ChEBI: Zimeldine is a member of styrenes.

Manufacturing Process

To 9 g of n-butyl lithium in 200 ml of dry ether 20 g of 3-bromopyridine is added as quickly as possible at -40°C without raising the temperature. When the addition is finished the mixture is stirred for another 30 minutes. Thereafter 32.5 g of ω-dimethylamino-4'-bromopropiophenone is added in such a way that the temperature does not exceed -40°C. The cooling is discontinued and the mixture is stirred during the night whereupon the reaction mixture is poured onto ice and diluted HCl, which is washed with ether and is extracted with 20 ml of methylene dichloride. The methylene dichloride is dried and evaporated. The crystals are dissolved in water, which then is made alkaline with a solution of Na 2 CO 3 , is extracted with ether, dried, and evaporated and recrystallized from isopropyl ether, petroleum ether 1:1. Yield 4 g of 1-(4'-bromophenyl)-3-(N,N-dimethylamino)-1-(3''-pyridyl)- propanol. Melting point 67°C.
3.6 g of 1-(4'-bromophenyl)-3-(N,N-dimethylamino)-1-(3''-pyridyl)-propanol are dissolved in 15 ml of 85% H 2 SO 4 and heated at 170°C for 10 minutes. The reaction mixture is poured into 60 ml of water, which is then made alkaline with 10 N NaOH, and is extracted with 2 x 25 ml of ether. The ether is dried with Na 2 SO 4 , treated with active carbon and evaporated. The residue is dissolved in 25 ml of acetone and an equivalent amount of oxalic acid dissolved in 25 ml of acetone is added. The precipitate obtained is filtered off, is dissolved in 50 ml of water, which is made alkaline with 10 N NaOH and is extracted with 2 x 25 ml of ether. The ether solution is dried with Na 2 SO 4 and is filtered, whereupon dry HCl is introduced. The precipitate obtained is filtered off. Yield 1.2 g of 3-(4'-bromophenyl)-3-(3''-pyridyl)- dimethylallylamine dihydrochloride (H 102/09). Melting point 193°C.

brand name

Normid;Normud;Zelmidine.

Therapeutic Function

Antidepressant

World Health Organization (WHO)

Zimeldine, an inhibitor of serotonin uptake, was introduced in 1982 for the treatment of depressive illness. By 1983 its use had been associated with incidences of hypersensitivity of varying severity and serious neurological side effects including the Guillain-Barr, syndrome. Following discussions with the National Board of Health and Welfare of Sweden, the major manufacturer decided to withdraw the drug on a worldwide basis.

Biological Activity

5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC 50 values are 0.33, 8.2 and 12 μ M respectively). Modulates nociception and induces hyperglycemia in vivo , and is an orally active antidepressant.

ZIMELIDINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ZIMELIDINE DIHYDROCHLORIDE Suppliers

Canada 1 China 22 Europe 1 Germany 2 India 3 Switzerland 1 United Kingdom 3 United States 7 Global 40

TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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United States Biological

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Waterstone Technology, LLC

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Medical Isotopes

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3B Scientific Corporation

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MP Biomedicals, Inc.

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56775-88-3, ZIMELIDINE DIHYDROCHLORIDERelated Search:

Allylamine (Z)-Zimeldine N-oxide Zimeldine Hydrochloride ZIMELIDINE 2HCL,ZIMELIDINE DIHYDROCHLORIDE SEROTONIN UPT AKE INHI,ZIMELIDINE DIHYDROCHLORIDE SEROTONIN UPT AKE INHI (E)-Zimelidine,(E)-Zimeldine ZIMELIDINE DIHYDROCHLORIDE Zimeldine-D6,Zimelidine-d6

cis-h102/09

cis-Zimelidine

H-102/09

(Z)-3-[1-(p-Bromophenyl)-3-(dimethylamino)propenyl]pyridine

(Z)-Zimelidine

3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine

3-(p-bromophenyl)-n,n-dimethyl-3-(3-pyridyl)-allylamin

Allylamine, 3-(p-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)-

cis-H 102/09

n-dimethyl-3-(3-pyridinyl)-3-(4-bromophenyl)-(z)-2-propen-1-amin

Zimeldine

Zimelidine

(Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridyl)-2-propen-1-amine

(Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine

2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (Z)-

D015031

Hydrochloride, zimeldine

Hydrochloride, zimelidine

Zelmid

(2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine

2-Propen-1-aMine, 3-(4-broMophenyl)-N,N-diMethyl-3-(3-pyridinyl)-, (2Z)-

ZIMELIDINE DIHYDROCHLORIDE

ZIMELIDINE DIHYDROCHLORIDE MONOHYDRATE

(Z)-3-(4-BROMOPHENYL)-N,N-DIMETHYL-3-(3-PYRIDINYL)-2-PROPEN-1-AMINE DIHYDROCHLORIDE

(2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine

(z)-3-(4’-bromophenyl)-3-(3’’-pyridyl)dimethylallylamine

(Z)-3-(4'-Bromophenyl)-3-(3''-pyridyl)dimethylallylamine

(2Z)-3-(4-BROMOPHENYL)-N,N-DIMETHYL-3-(3-PYRINDINYL)-2-PROPEN-1-AMINE DIHYDROCHLORIDE

56775-88-3

C16H17BrN22HCl

C16H17BrN2

C16H19BrCl2N2

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