ChemicalBook > CAS DataBase List > 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine

2-(7-methoxy-4-methylquinazolin-2-yl)guanidine

Product Name
2-(7-methoxy-4-methylquinazolin-2-yl)guanidine
CAS No.
37836-90-1
Chemical Name
2-(7-methoxy-4-methylquinazolin-2-yl)guanidine
Synonyms
MPO inhibitor 28;MPO-IN-28 ，S0316;MPO-IN-28, 10 mM in DMSO;Myeloperoxidase inhibitor 28;2-(7-methoxy-4-methylquinazolin-2-yl)guanidine;1-(7-Methoxy-4-methylquinazolin-2-yl)guanidine;Guanidine, N-(7-methoxy-4-methyl-2-quinazolinyl)-;inhibit,Inhibitor,Glutathione Peroxidase,MPOIN28,MPO IN 28
CBNumber
CB44343053
Molecular Formula
C11H13N5O
Formula Weight
231.25
MOL File
37836-90-1.mol
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2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Property

Boiling point:
442.7±37.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO:34.37(Max Conc. mg/mL);148.6(Max Conc. mM)
form 
A solid
pka
7.83±0.30(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0087062
Product name
MPO-IN-28
Purity
98.10%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0087062
Product name
MPO-IN-28
Purity
98.10%
Packaging
5mg
Price
$150
Updated
2021/12/16
CSNpharm
Product number
CSN24185
Product name
MPO-IN-28
Packaging
10mg
Price
$233
Updated
2021/12/16
DC Chemicals
Product number
DC11769
Product name
MPO-IN-28
Purity
>98%
Packaging
100mg
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
DC11769
Product name
MPO-IN-28
Purity
>98%
Packaging
250mg
Price
$950
Updated
2021/12/16
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2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Chemical Properties,Usage,Production

Uses

MPO-IN-28 is a selective myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM. MPO-IN-28 can effectively inhibit MPO-mediated low-density lipoprotein oxidation with an IC50 of 90 nM[1].

Biological Activity

Compound 18 is an agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) th at inhibit mosquito attraction to humans and other hosts. Compound 18 suppresses biting and blood-feeding on a live host. Also, It (MPO-IN-28) is a potent myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM.

References

[1] Soubhye J, et al. Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. J Med Chem. 2017 Aug 10;60(15):6563-6586. DOI:10.1021/acs.jmedchem.7b00285

2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Suppliers

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37836-90-1, 2-(7-methoxy-4-methylquinazolin-2-yl)guanidineRelated Search:


  • 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine
  • Myeloperoxidase inhibitor 28
  • MPO inhibitor 28
  • Guanidine, N-(7-methoxy-4-methyl-2-quinazolinyl)-
  • 1-(7-Methoxy-4-methylquinazolin-2-yl)guanidine
  • inhibit,Inhibitor,Glutathione Peroxidase,MPOIN28,MPO IN 28
  • MPO-IN-28, 10 mM in DMSO
  • MPO-IN-28 ，S0316
  • 37836-90-1