5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE

Product Name: 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE
CAS No.: 154934-97-1
Chemical Name: 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE
Synonyms: 5-Ethoxycar;5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE;Ethyl 4-(trifluoroMethyl)-2-hydroxypyriMidine-5-carboxylate;ETHYL 2-HYDROXY-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;Ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate;5-Ethoxycarbonyl-4-(trifluoromethyl)-1H-pyrimidin-2-one, tech;5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)-PYRIMIDIN-2-(1H)-ONE TECH;Ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate , 90+%;ETHYL 2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLATE;5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL) -N PYRIMIDIN-2-(1H)-ONE, TECH.
CBNumber: CB4437431
Molecular Formula: C8H7F3N2O3
Formula Weight: 236.15
MOL File: 154934-97-1.mol

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5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE Property

Melting point:: 165 °C
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.03±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 154934-97-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
Hazard Note: Irritant
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H977598
Product name: 2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylicAcidEthylEster
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 002988
Product name: 5-Ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1H)-one
Purity: tech
Packaging: 1g
Price: $19
Updated: 2021/12/16

Apolloscientific

Product number: PC3165
Product name: Ethyl1,2-dihydro-2-oxo-6-(trifluoromethyl)pyrimidine-5-carboxylate
Purity: tech
Packaging: 1g
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-3-54
Product name: 5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one
Packaging: 1g
Price: $32
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK160865
Product name: Ethyl4-(trifluoromethyl)-2-hydroxypyrimidine-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $46
Updated: 2021/12/16

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5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

122-51-0

372-31-6

57-13-6

154934-97-1

Urea (2.9 g, 0.05 mol), ethyl 4,4,4-trifluoro-3-oxobutanoate (8.9 g, 0.05 mol) and triethyl orthoformate (7.9 g, 0.05 mol) were dissolved in ethanol (10 mL) under nitrogen protection. The reaction mixture was heated to 80 °C and maintained at this temperature for 4 hours. Upon completion of the reaction, the mixture was cooled to 20 °C and sodium ethanolate solution (21 wt% ethanol solution, 16.9 g, 0.05 mol) was slowly added with stirring for 15 minutes. After addition, stirring of the reaction mixture was continued for 2 hours. Subsequently, water (75 mL) and acetic acid (2 mL) were added to the reaction system at 20 to 30 °C. The resulting slurry was filtered and the filter cake was washed with water (20 mL) and dried at 45 °C. A final product of 8.2 g (72% yield) of the target product ethyl 2-hydroxy-4-trifluoromethyl-5-pyrimidinecarboxylate was obtained as a white solid.1H NMR (400 MHz, (CD3)2SO): δ = 8.69 (s, 1H), 4.24 (q, J = 7.1 Hz, 2H), 1.28 (t, J = 7.1 Hz, 3H). 13C NMR (100 MHz, (CD3)2SO): δ = 161.4, 158.7 (q, J = 35 Hz), 155.5, 154.7, 119.2 (q, J = 278 Hz), 105.7, 61.3, 13.7.

References

[1] Patent: WO2006/48297, 2006, A1. Location in patent: Page/Page column 5; 6

5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE Suppliers

Belgium 1 China 64 Germany 3 India 2 United Kingdom 8 United States 20 Global 98

Creasyn Finechem(Tianjin) Co., Ltd.

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View Lastest Price from 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE 154934-97-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE 154934-97-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

154934-97-1, 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONERelated Search:

1,1,1-TRIFLUOROBUTENE-3 Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-HYDROXY-4-METHYLPYRIMIDINE Ethyl 4,4,4-trifluorobutyrate ETHYL-2-ETHOXY-4-TRIFLUOROMETHYL PYRIMIDINE-5-CARBOXYLATE 5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE METHYL 3-AMINOACRYLATE 2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID METHYL 4,4,4-TRIFLUOROBUTYRATE 2-Hydroxy-4-(trifluoromethyl)pyrimidine 4-trifluoromethyl-2-hydroxy-pyrimidine-5-carboxylic acid 2(1H)-Pyrimidinone, 5-(hydroxymethyl)- (9CI) ETHYL-4-TRIFLUOROMETHYL PYRIMIDINE-5-CARBOXYLATE

5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE

ETHYL 2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLATE

Ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate

ETHYL 2-HYDROXY-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

2-Oxo-6-trifluoroMethyl-1,2-dihydro-pyriMidine-5-carboxylic acid ethyl ester

Ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate , 90+%

Ethyl 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyrimidine-5-carboxylate, tech

Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate, Ethyl 1,2-dihydro-2-oxo-4-(trifluoromethyl)pyrimidine-5-carboxylate

Ethyl 4-(trifluoroMethyl)-2-hydroxypyriMidine-5-carboxylate

5-Ethoxycarbonyl-4-(trifluoromethyl)-1H-pyrimidin-2-one, tech

5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)-PYRIMIDIN-2-(1H)-ONE TECH

5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL) -N PYRIMIDIN-2-(1H)-ONE, TECH.

ETHYL 2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLATE, TECH.

5-Ethoxycar

Ethyl 2-oxo-6-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate

5-Pyrimidinecarboxylic acid, 1,2-dihydro-2-oxo-6-(trifluoromethyl)-, ethyl ester

Ethyl 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyrimidine-5-carboxylate, 97%

Ethyl 1,2-dihydro-2-oxo-4-(trifluoromethyl)pyrimidine-5-carboxylate

5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE ISO 9001：2015 REACH

154934-97-1

C8H7F3N2O3