ChemicalBook > CAS DataBase List > 7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione

7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione

Product Name
7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione
CAS No.
488097-06-9
Chemical Name
7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione
Synonyms
VU 0650991;GLP-1R Antagonist 1;GLP-1R Antagonist 1, 10 mM in DMSO;GLP 1R Antagonist 1,GLP1R Antagonist 1;7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione;Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, 7-(4-chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)-
CBNumber
CB44599881
Molecular Formula
C16H11ClF6N4O2
Formula Weight
440.7275592
MOL File
488097-06-9.mol
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7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6355
Product name
VU0650991
Purity
≥98%(HPLC)
Packaging
10
Price
$224
Updated
2021/12/16
ChemScene
Product number
CS-0020879
Product name
GLP-1RAntagonist1
Purity
99.48%
Packaging
25mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0020879
Product name
GLP-1RAntagonist1
Purity
99.48%
Packaging
50mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0020879
Product name
GLP-1RAntagonist1
Purity
99.48%
Packaging
100mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0020879
Product name
GLP-1RAntagonist1
Purity
99.48%
Packaging
5mg
Price
$110
Updated
2021/12/16
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7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione Chemical Properties,Usage,Production

Description

VU 0650991 is a non-competitive GLP-1 antagonist that is orally bioavailable and acts as a brain penetrant.

Uses

GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].

in vivo

GLP-1R Antagonist 1 (compound 5d) (10 mg/kg, p.o.) increases the levels of blood glucose and decreases the levels of blood insulin in male Sprague-Dawley rats[1].

1.19
Pharmacokinetic Analysis in MC38 Syngeneic Model[1]
RouteDose (mg/kg)CLp (mL/min/kg)t1/2 (min)Vss (L/kg)%F
i.v., p.o.1, 34.795873.5750

storage

Store at -20°C

References

[1] Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017. DOI:10.1021/acs.jmedchem.6b01706

7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione Suppliers

CHINA 19 Finland 1 United States 3 Global 23
ShangHai Caerulum Pharma Discovery Co., Ltd.
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United States
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marketing@targetmol.com
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488097-06-9, 7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dioneRelated Search:


  • 7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione
  • VU 0650991
  • GLP-1R Antagonist 1
  • Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, 7-(4-chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)-
  • GLP 1R Antagonist 1,GLP1R Antagonist 1
  • GLP-1R Antagonist 1, 10 mM in DMSO
  • 488097-06-9