MIK665

Product Name: MIK665
CAS No.: 1799631-75-6
Chemical Name: MIK665
Synonyms: S64315;MIK665;MIK665,S64315;S64315 (MIK665);MIK665, 10 mM in DMSO;S64315 (MIK665) ，S8836;S64315(MIK665 ，S-64315);MIK665 (S-64315, MIK-665);(2S)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid;(αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]benzenepropanoic acid
CBNumber: CB44635293
Molecular Formula: C47H44ClFN6O6S
Formula Weight: 875.41
MOL File: 1799631-75-6.mol

More

Less

MIK665 Property

Boiling point:: 909.4±65.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 2.53±0.11(Predicted)
color: White to off-white
InChIKey: PKYIMGFMRFVOMB-UHFFFAOYSA-N
SMILES: O(C1N=CN=C2SC(C3C=CC(F)=CC=3)=C(C3C=CC(OCCN4CCN(C)CC4)=C(Cl)C=3C)C=12)C(C(=O)O)CC1C=CC=CC=1OCC1C=CN=C(C2C=CC=CC=2OC)N=1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Ambeed

Product number: A169993
Product name: (5S)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoicacid
Purity: 99+%
Packaging: 5mg
Price: $488
Updated: 2021/12/16

Ambeed

Product number: A169993
Product name: (5S)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoicacid
Purity: 99+%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

Ambeed

Product number: A169993
Product name: (5S)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoicacid
Purity: 99+%
Packaging: 50mg
Price: $2050
Updated: 2021/12/16

More

Less

MIK665 Chemical Properties,Usage,Production

Uses

MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor[1]. MIK665 has an IC50 of 1.81 nM for MCL1[2].

IC 50

Mcl-1: 1.81 nM (IC₅₀)

References

[1] Mukherjee N, et al. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers (Basel). 2020;12(8):2182. Published 2020 Aug 5. DOI:10.3390/cancers12082182
[2] Zoltán SZLáVIK, et al. New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them. WO2016207225A1.

MIK665 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MIK665 Suppliers

China 70 United States 5 Global 75

SuZhou GoodChemTech Co., Ltd

Tel: 18136139868; 18136139868
Email: jinlun@goodchemtech.cn
Country: China
ProdList: 302
Advantage: 58

Elucigen bio

Tel: 13501719342; 13501719342
Email: wayne.zheng@elucigenbio.com
Country: China
ProdList: 5000
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4800
Advantage: 55

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9729
Advantage: 58

1799631-75-6, MIK665Related Search:

MIK665

MIK665,S64315

S64315 (MIK665)

(2S)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid

MIK665 (S-64315, MIK-665)

S64315

Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]-, (αR)-

(5S)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid

S64315(MIK665 ，S-64315)

(αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]benzenepropanoic acid

MIK665, 10 mM in DMSO

S64315 (MIK665) ，S8836

1799631-75-6

C47H44ClFN6O6S