Apararenone
- Product Name
- Apararenone
- CAS No.
- 945966-46-1
- Chemical Name
- Apararenone
- Synonyms
- MT-3995;Apararenone;Apararenone/MT-3995;Apararenone, 10 mM in DMSO;inhibit,Inhibitor,Mineralocorticoid Receptor,MT 3995,Apararenone,MT3995;Methanesulfonamide, N-[4-(4-fluorophenyl)-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazin-7-yl]-;N-(4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide
- CBNumber
- CB44635369
- Molecular Formula
- C17H17FN2O4S
- Formula Weight
- 364.39
- MOL File
- 945966-46-1.mol
Apararenone Property
- Boiling point:
- 594.3±60.0 °C(Predicted)
- Density
- 1.389±0.06 g/cm3(Predicted)
- solubility
- DMSO: Sparingly soluble: 1-10 mg/ml
- form
- Solid
- pka
- 8.02±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0030433
- Product name
- Apararenone
- Purity
- 98.98%
- Packaging
- 5mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CS-0030433
- Product name
- Apararenone
- Purity
- 98.98%
- Packaging
- 10mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- CS-0030433
- Product name
- Apararenone
- Purity
- 98.98%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
Apararenone Chemical Properties,Usage,Production
Uses
Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
in vivo
Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].
References
[1] Kolkhof P, et al. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development. J Endocrinol. 2017 Jul;234(1):T125-T140. DOI:10.1530/JOE-16-0600
[2] TORU IIJIMA*, TAKAYUKI KAWAGUCHI Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist[J]. Journal of Medicinal Chemistry, 2022, 65 12: 8127-8143. DOI: 10.1021/acs.jmedchem.2c00402
Apararenone Preparation Products And Raw materials
Raw materials
Preparation Products
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