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-Defensin-4 (human) (trifluoroacetate salt)

Product Name
-Defensin-4 (human) (trifluoroacetate salt)
CAS No.
370570-43-7
Chemical Name
-Defensin-4 (human) (trifluoroacetate salt)
Synonyms
β-Defensin-4 (human) trifluoroacetate salt;-Defensin-4 (human) (trifluoroacetate salt)
CBNumber
CB44665621
Molecular Formula
C182H296F3N63O54S6
Formula Weight
4480.0725496
MOL File
370570-43-7.mol
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-Defensin-4 (human) (trifluoroacetate salt) Property

storage temp. 
Store at -20°C
solubility 
Water: 1 mg/ml
form 
A lyophilized powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24579
Product name
β-Defensin-4 (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
100μg
Price
$275
Updated
2024/03/01
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-Defensin-4 (human) (trifluoroacetate salt) Chemical Properties,Usage,Production

Description

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.2 β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.4 It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.2,5

References

1. Lehrer, R.I. Primate defensins Nat. Rev. Microbiol. 2(9),727-738(2004).
2. García, J.R., Krause, A., Schulz, S., et al. Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB J. 15(10),1819-1821(2001).
3. Niyonsaba, F., Ushio, H., Nakano, N., et al. Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines J. Invest. Dermatol. 127(3),594-604(2007).
4. Niyonsaba, F., Ushio, H., Hara, M., et al. Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells J. Immunol. 184(7),3526-3534(2010).
5. Sharma, H., and Nagaraj, R. Antimicrobial activity of human β-defensin 4 analogs: Insights into the role of disulfide linkages in modulating activity Peptides 38(2),255-265(2012).

-Defensin-4 (human) (trifluoroacetate salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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-Defensin-4 (human) (trifluoroacetate salt) Suppliers

China 4 United States 2 Global 6
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
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58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19699
Advantage
58

370570-43-7, -Defensin-4 (human) (trifluoroacetate salt)Related Search:


  • -Defensin-4 (human) (trifluoroacetate salt)
  • β-Defensin-4 (human) trifluoroacetate salt
  • 370570-43-7