ChemicalBook > CAS DataBase List > BLU-782

BLU-782

Product Name: BLU-782
CAS No.: 2141955-96-4
Chemical Name: BLU-782
Synonyms: BLU-782;ALK2-IN-1;Fidrisertib;BLU782;BLU 782;Blu-782, 10 mM in DMSO;(3R)-oxolan-3-yl 4-(6-{5-[4-ethoxy-1-(propan-2-yl)piperidin-4-yl]pyridin-2-yl}pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate;(R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1,2-b]pyridazin-4-yl]-, (3R)-tetrahydro-3-furanyl ester
CBNumber: CB44667650
Molecular Formula: C31H42N6O4
Formula Weight: 562.7
MOL File: 2141955-96-4.mol

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BLU-782 Property

storage temp.: 2-8°C
solubility: DMF: insol; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form: A solid
color: Yellow to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A1177054
Product name: (R)-Tetrahydrofuran-3-yl4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate
Purity: 98+%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

Ambeed

Product number: A1177054
Product name: (R)-Tetrahydrofuran-3-yl4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate
Purity: 98+%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Ambeed

Product number: A1177054
Product name: (R)-Tetrahydrofuran-3-yl4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate
Purity: 98+%
Packaging: 25mg
Price: $304
Updated: 2021/12/16

Ambeed

Product number: A1177054
Product name: (R)-Tetrahydrofuran-3-yl4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate
Purity: 98+%
Packaging: 50mg
Price: $487
Updated: 2021/12/16

Ambeed

Product number: A1177054
Product name: (R)-Tetrahydrofuran-3-yl4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate
Purity: 98+%
Packaging: 100mg
Price: $730
Updated: 2021/12/16

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BLU-782 Chemical Properties,Usage,Production

Uses

ALK2-IN-1 is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM[1].

References

[1] Natasja Brooijmans, et al. Inhibitors of activin receptor-like kinase. WO2017181117A1.

BLU-782 Preparation Products And Raw materials

Raw materials

Preparation Products

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2141955-96-4, BLU-782Related Search:

Pralsetinib Avapritinib BLU 9931 BLU-945

BLU-782

(R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4-yl)pyridin-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate

BLU782;BLU 782

ALK2-IN-1

1-Piperazinecarboxylic acid, 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1,2-b]pyridazin-4-yl]-, (3R)-tetrahydro-3-furanyl ester

(3R)-oxolan-3-yl 4-(6-{5-[4-ethoxy-1-(propan-2-yl)piperidin-4-yl]pyridin-2-yl}pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate

Fidrisertib

Blu-782, 10 mM in DMSO

2141955-96-4