EB-3D

Product Name: EB-3D
CAS No.: 1839150-63-8
Chemical Name: EB-3D
Synonyms: EB-3D;ChoK inhibitor EB-3D;EB-3D, 10 mM in DMSO;1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;lipid,inhibit,lymphoblastic,AMP-activated protein kinase,EB3D,acute,tumorigenesis,Apoptosis,homeostasis,dephosphorylation,AMPK,Inhibitor,EB 3D,leukemia,EB-3D,HepG2
CBNumber: CB44667867
Molecular Formula: C30H36BrN4O2+
Formula Weight: 564.55
MOL File: 1839150-63-8.mol

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EB-3D Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: 50 mg/mL (77.59 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087006
Product name: EB-3D
Purity: 98.78%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0087006
Product name: EB-3D
Purity: 98.78%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0087006
Product name: EB-3D
Purity: 98.78%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

Ambeed

Product number: A1228334
Product name: 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium)bromide
Purity: 98%
Packaging: 50mg
Price: $154
Updated: 2021/12/16

Ambeed

Product number: A1228334
Product name: 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium)bromide
Purity: 98%
Packaging: 100mg
Price: $227
Updated: 2021/12/16

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EB-3D Chemical Properties,Usage,Production

Uses

EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3].

in vivo

EB-3D (1 mg/kg; i.p.; every other day) impairs mammary tumor growth in syngeneic orthotopic E0771-C57BL/6 mouse model^[4].
EB-3D (2.5 mg/kg; every other day for 4 weeks) shows a reduction of the number of spontaneous lung macro- and micrometastasis^[4].

Animal Model:	E0771-C57BL/6 mice^[4]
Dosage:	I.p.; every other day for 4 weeks
Administration:	2.5 mg/kg
Result:	A reduction of the number of spontaneous lung macro- and micrometastasis.

References

[1] Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223. DOI:10.1016/j.bcp.2018.07.004
[2] Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9(1):5109. DOI:10.1038/s41598-019-40885-z
[3] Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1). DOI:10.1038/srep23793
[4] Mariotto E, et al. Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer. Cancers (Basel). 2018;10(10):391. Published 2018 Oct 22. DOI:10.3390/cancers10100391

EB-3D Preparation Products And Raw materials

Raw materials

Preparation Products

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EB-3D Suppliers

China 37 United States 4 Global 41

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
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Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 021-61350663 15502154572
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
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Henan Weituxi Chemical Technology Co., Ltd.

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Zhengzhou anmousse chemical products co. LTD

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cjbscvictory

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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
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1839150-63-8, EB-3DRelated Search:

EB-3D

ChoK inhibitor EB-3D

1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide

lipid,inhibit,lymphoblastic,AMP-activated protein kinase,EB3D,acute,tumorigenesis,Apoptosis,homeostasis,dephosphorylation,AMPK,Inhibitor,EB 3D,leukemia,EB-3D,HepG2

EB-3D, 10 mM in DMSO

1839150-63-8