Foretinib-Based PROTAC 7

Product Name: Foretinib-Based PROTAC 7
CAS No.: 2230821-68-6
Chemical Name: Foretinib-Based PROTAC 7
Synonyms: Foretinib-Based PROTAC 7;N'1-{3-fluoro-4-[(7-{3-[3-(2-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)propoxy]propoxy}-6-methoxyquinolin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CBNumber: CB44667908
Molecular Formula: C58H65F2N7O11S
Formula Weight: 1106.25
MOL File: 2230821-68-6.mol

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Foretinib-Based PROTAC 7 Property

Boiling point:: 1226.5±65.0 °C(Predicted)
Density: 1.341±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO|55.31|50|
pka: 13.14±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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Foretinib-Based PROTAC 7 Chemical Properties,Usage,Production

Description

SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells.

storage

Store at -20°C

Foretinib-Based PROTAC 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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Foretinib-Based PROTAC 7 Suppliers

China 10 United States 2 Global 12

Beijing Jin Ming Biotechnology Co., Ltd.

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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Nantong QuanYi Biotechnology Co., Ltd

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2230821-68-6, Foretinib-Based PROTAC 7Related Search:

Foretinib-Based PROTAC 7

1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

N'1-{3-fluoro-4-[(7-{3-[3-(2-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)propoxy]propoxy}-6-methoxyquinolin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

2230821-68-6

C58H65F2N7O11S