ChemicalBook > CAS DataBase List > Foretinib-Based PROTAC 7
Foretinib-Based PROTAC 7
- Product Name
- Foretinib-Based PROTAC 7
- CAS No.
- 2230821-68-6
- Chemical Name
- Foretinib-Based PROTAC 7
- Synonyms
- Foretinib-Based PROTAC 7;N'1-{3-fluoro-4-[(7-{3-[3-(2-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)propoxy]propoxy}-6-methoxyquinolin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- CBNumber
- CB44667908
- Molecular Formula
- C58H65F2N7O11S
- Formula Weight
- 1106.25
- MOL File
- 2230821-68-6.mol
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Foretinib-Based PROTAC 7 Property
- Boiling point:
- 1226.5±65.0 °C(Predicted)
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO|55.31|50|
- pka
- 13.14±0.70(Predicted)
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Foretinib-Based PROTAC 7 Chemical Properties,Usage,Production
Description
SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells.
storage
Store at -20°C
Foretinib-Based PROTAC 7 Preparation Products And Raw materials
Raw materials
Preparation Products
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Foretinib-Based PROTAC 7 Suppliers
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- +1-781-999-5354 +1-00000000000
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- Country
- United States
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