MW-150 hydrochloride
- Product Name
- MW-150 hydrochloride
- CAS No.
- 1923773-01-6
- Chemical Name
- MW-150 hydrochloride
- Synonyms
- MW01-18-150SRM;MW-150 hydrochloride;MW01-18-150SRM;MW 150;MW150;MW01-18-150SRM hydrochloride
- CBNumber
- CB44668248
- Molecular Formula
- C24H24ClN5
- Formula Weight
- 417.94
- MOL File
- 1923773-01-6.mol
N-Bromosuccinimide Price
- Product number
- orb611279
- Product name
- MW-150 hydrochloride
- Purity
- >98%
- Packaging
- 100mg
- Price
- $912.9
- Updated
- 2021/12/16
- Product number
- orb611279
- Product name
- MW-150 hydrochloride
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1654.1
- Updated
- 2021/12/16
- Product number
- orb611279
- Product name
- MW-150 hydrochloride
- Purity
- >98%
- Packaging
- 1g
- Price
- $3282.7
- Updated
- 2021/12/16
- Product number
- DC11828
- Product name
- MW-150hydrochloride
- Purity
- >98%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
MW-150 hydrochloride Chemical Properties,Usage,Production
Uses
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
in vivo
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; oral daily for 3 4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 hydrochloride (MW01-18-150SRM hydrochloride) (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].
| Animal Model: | APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta) [1] |
| Dosage: | 2.5 mg/kg |
| Administration: | Oral daily; 3-4 months (until cognitive impairment is present) |
| Result: | Improved the Tg mice performance in both cognitive tests. |
IC 50
p38α: 101 nM (Ki)
References
[1] Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. DOI:10.1021/acschemneuro.5b00002
MW-150 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
MW-150 hydrochloride Suppliers
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- 15911056312
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- Country
- China
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