AZ-1

Product Name: AZ-1
CAS No.: 2165322-94-9
Chemical Name: AZ-1
Synonyms: USP25/28 inhibitor AZ1;USP25 and 28 inhibitor AZ-1;AZ-1;AZ-1;AZ 1;AZ1;AZ1 USP25/28 inhibitor;USP25/28 inhibitor AZ1, 10 mM in DMSO;2-((5-bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethanol;2-((5-Bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethan-1-ol;Ethanol, 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-;Deubiquitinase,USP-25/28 inhibitor AZ1,USP25/28 inhibitor AZ1,inhibit,AZ 1,Inhibitor,AZ-1,DUBs
CBNumber: CB44668637
Molecular Formula: C17H16BrF4NO2
Formula Weight: 422.21
MOL File: 2165322-94-9.mol

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AZ-1 Property

Boiling point:: 478.5±40.0 °C(Predicted)
Density: 1.488±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 250 mg/mL (592.12 mM); Water: < 0.1 mg/mL (insoluble)
form: Solid
pka: 14.74±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0065552
Product name: USP25/28inhibitorAZ1
Purity: 98.10%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0065552
Product name: USP25/28inhibitorAZ1
Purity: 98.10%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0065552
Product name: USP25/28inhibitorAZ1
Purity: 98.10%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0065552
Product name: USP25/28inhibitorAZ1
Purity: 98.10%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0065552
Product name: USP25/28inhibitorAZ1
Purity: 98.10%
Packaging: 100mg
Price: $1450
Updated: 2021/12/16

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AZ-1 Chemical Properties,Usage,Production

Biological Activity

AZ1 is a potent and selective dual USP25 & USP28 deubiquitinase (DUBs) inhibitor (USP25/28 IC50 = 0.62/0.7 nM by Ub-Rh110 assay) th at induces HCT116 cellular c-Myc degradation (20-100 μM for 3h or 60 μM for 0.3-3h). AZ1 exhibits antiproliferation activity in cancer cultures (IC50 ≤20 μM; HCT116, HT29 and SW480) and anti-tumor efficacy in an orthotopic model of lung SCC tumours in mice in vivo (125 mg/kg or 375 mg/kg i.p. once every three days, 6 injections total).

AZ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ-1 Suppliers

China 45 United States 4 Global 49

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

2165322-94-9, AZ-1Related Search:

USP25 and 28 inhibitor AZ-1

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USP25/28 inhibitor AZ1, 10 mM in DMSO

2165322-94-9

C17H16BrF4NO2