(2R,6R)-Hydroxynorketamine
- Product Name
- (2R,6R)-Hydroxynorketamine
- CAS No.
- 1430202-69-9
- Chemical Name
- (2R,6R)-Hydroxynorketamine
- Synonyms
- (2R,6R)-Hydroxynorketamine;(2R,6R)-Hydroxynorketamine hydrochloride;(2R,6R)-Hydroxynorketamine hydrochloride >=98% (HPLC);(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;(2S,6R)-2-amino-3-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride
- CBNumber
- CB44668950
- Molecular Formula
- C12H15Cl2NO2
- Formula Weight
- 276.16
- MOL File
- 1430202-69-9.mol
(2R,6R)-Hydroxynorketamine Property
- storage temp.
- 2-8°C
- solubility
- DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -95 to -115°, c = 1 in H2O
- Water Solubility
- H2O: 25mg/mL, clear
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1873
- Product name
- (2R,6R)-Hydroxynorketamine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- SML1873
- Product name
- (2R,6R)-Hydroxynorketamine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $530
- Updated
- 2024/03/01
- Product number
- 19603
- Product name
- (2R,6R)-Hydroxynorketamine (hydrochloride)
- Packaging
- 1mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 19603
- Product name
- (2R,6R)-Hydroxynorketamine (hydrochloride)
- Packaging
- 5mg
- Price
- $404
- Updated
- 2024/03/01
- Product number
- 6094
- Product name
- (2R,6R)-Hydroxynorketamine hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $298
- Updated
- 2021/12/16
(2R,6R)-Hydroxynorketamine Chemical Properties,Usage,Production
Uses
cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone Hydrochloride is a metabolite of ketamine and increase AMPA receptor-mediated excitatory post-synaptic potentials in the CA 1 region of hippocampal slices. Anti-depressive effects.
Biochem/physiol Actions
(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.
storage
Store at RT
(2R,6R)-Hydroxynorketamine Preparation Products And Raw materials
Raw materials
Preparation Products
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