GSK269962 Hydrochloride

Product Name: GSK269962 Hydrochloride
CAS No.: 2095432-71-4
Chemical Name: GSK269962 Hydrochloride
Synonyms: GSK269962 HCl;GSK269962A HCl ，S7687;GSK269962 Hydrochloride;GSK269962A hydrochloride;N-(3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl)oxy)phenyl)-4-(2-morpholinoethoxy)benzamide hydrochloride
CBNumber: CB44672087
Molecular Formula: C29H31ClN8O5
Formula Weight: 607.07
MOL File: 2095432-71-4.mol

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GSK269962 Hydrochloride Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 100 mg/mL (164.73 mM);Ethanol: 28 mg/mL (46.12 mM)
form: Solid
color: Off-white to light yellow
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 4701DN
Product name: GSK269962hydrochloride
Packaging: 100mg
Price: $598
Updated: 2021/12/16

AK Scientific

Product number: 4701DN
Product name: GSK269962hydrochloride
Packaging: 1g
Price: $2751
Updated: 2021/12/16

CSNpharm

Product number: CSN19208
Product name: GSK269962HCl
Packaging: 5mg
Price: $64
Updated: 2021/12/16

Ambeed

Product number: A105790
Product name: GSK269962hydrochloride
Purity: 98+%
Packaging: 5mg
Price: $194
Updated: 2021/12/16

Arctom

Product number: AS428096
Product name: GSK269962hydrochloride
Purity: ≥98%
Packaging: 10mg
Price: $249
Updated: 2021/12/16

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GSK269962 Hydrochloride Chemical Properties,Usage,Production

Uses

GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. GSK269962A hydrochloride has anti-inflammatory and vasodilatory activities[1].

Biological Activity

GSK269962A HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 of 1.6 nM and 4 nM for ROCK1 and ROCK2, respectively.

in vivo

GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial^[1].

Animal Model:	Male Sprague-Dawley rats (350-400g)^[1]
Dosage:	0.3, 1, and 3 mg/kg
Administration:	Oral gavage; 12 hours
Result:	Induced a dose-dependent reduction in blood pressure.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> MSK1
(Cell-free assay)

Target	Value
ROCK1 (Cell-free assay)	1.6 nM
ROCK2 (Cell-free assay)	4 nM
49 nM
RSK1 (Cell-free assay)	132 nM

IC 50

ROCK1: 1.6 nM (IC₅₀); ROCK2: 4 nM (IC₅₀); RSK1: 132 nM (IC₅₀); MSK1: 49 nM (IC₅₀); AKT1: 955 nM (IC₅₀); AKT2: 1350 nM (IC₅₀); AKT3: 1510 nM (IC₅₀); CDK2: 3500 nM (IC₅₀); GSK3α: 1260 nM (IC₅₀)

References

[1] Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. DOI:10.1124/jpet.106.110635

GSK269962 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK269962 Hydrochloride Suppliers

China 19 India 1 United States 2 Global 22

Sichuan Yuehe Bio-Pharmaceutical Co.,Ltd

Tel: 028-82729560 18030702676
Fax: 028-82729560
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Country: China
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
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Country: United States
ProdList: 6391
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Energy Chemical

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Email: marketing1@energy-chemical.com
Country: China
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Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
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Country: China
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Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
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InvivoChem

Tel: 13549236410
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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: 4008200310
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Country: China
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2095432-71-4, GSK269962 HydrochlorideRelated Search:

GSK269962 Hydrochloride

GSK269962 HCl

GSK269962A hydrochloride

N-(3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl)oxy)phenyl)-4-(2-morpholinoethoxy)benzamide hydrochloride

GSK269962A HCl ，S7687

2095432-71-4