Verubecestat Trifluoroacetate

Product Name: Verubecestat Trifluoroacetate
CAS No.: 2095432-65-6
Chemical Name: Verubecestat Trifluoroacetate
Synonyms: Verubecestat (TFA);Verubecestat Trifluoroacetate;(R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate
CBNumber: CB44672249
Molecular Formula: C19H18F5N5O5S
Formula Weight: 523.44
MOL File: 2095432-65-6.mol

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Verubecestat Trifluoroacetate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 81 mg/mL (154.75 mM);Ethanol: 5 mg/mL (9.55 mM)
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A246701
Product name: (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide2,2,2-trifluoroacetate
Purity: 95%
Packaging: 100mg
Price: $121
Updated: 2021/12/16

Ambeed

Product number: A246701
Product name: (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide2,2,2-trifluoroacetate
Purity: 95%
Packaging: 250mg
Price: $241
Updated: 2021/12/16

Ambeed

Product number: A246701
Product name: (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide2,2,2-trifluoroacetate
Purity: 95%
Packaging: 1g
Price: $603
Updated: 2021/12/16

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Verubecestat Trifluoroacetate Chemical Properties,Usage,Production

Biological Activity

Verubecestat (MK-8931) Trifluoroacetat is a potent and selective beta-secretase inhibitor, a BACE1 inhibitor.

in vitro

Verubecestat(MK-8931) effectively reduces Aβ40 in cells, Ki：7.8 nM and IC50 ：13 nM.

in vivo

single oral dose of Verubecestat (MK-8931) to rats and cynomolgus monkeys significantly reduced cerebrospinal fluid (CSF) and cortical Aβ40. MK-8931 has an in vivo half-life of 20 hours, and is suitable for a once-daily dosing frequency.

target

Target	Value
BACE2 (Cell-free assay)	0.37 nM(Ki)
BACE1 (Cell-free assay)	1.75 nM(Ki)

Verubecestat Trifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Verubecestat Trifluoroacetate Suppliers

China 11 India 1 United States 3 Global 15

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44807
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3021
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
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InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
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Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
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Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
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Country: China
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Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 15801958784
Email: lihua@jskchem.com
Country: China
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Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3135
Advantage: 58

2095432-65-6, Verubecestat TrifluoroacetateRelated Search:

Verubecestat Trifluoroacetate

Verubecestat (TFA)

(R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate

2095432-65-6