DMHCA
- Product Name
- DMHCA
- CAS No.
- 79066-03-8
- Chemical Name
- DMHCA
- Synonyms
- DMHCA;Chol-5-en-24-amide, 3-hydroxy-N,N-dimethyl-, (3β)-
- CBNumber
- CB44718606
- Molecular Formula
- C26H43NO2
- Formula Weight
- 401.64
- MOL File
- 79066-03-8.mol
DMHCA Property
- Melting point:
- 189.5-190 °C
- Boiling point:
- 525.6±23.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 1 mg/ml
- form
- A solid
- pka
- 15.03±0.70(Predicted)
- color
- White to off-white
- SMILES
- C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N(C)C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
N-Bromosuccinimide Price
- Product number
- SML4114
- Product name
- DMHCA
- Purity
- ≥98% (HPLC)
- Packaging
- 1 unit
- Price
- $399
- Updated
- 2025/07/31
- Product number
- CS-0103576
- Product name
- DMHCA
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0103576
- Product name
- DMHCA
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0103576
- Product name
- DMHCA
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0103576
- Product name
- DMHCA
- Packaging
- 50mg
- Price
- $350
- Updated
- 2021/12/16
DMHCA Chemical Properties,Usage,Production
Uses
DMHCA has been used as LXR activator to tre at retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.', 'It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.
Biological Activity
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.', 'DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.
in vivo
DMHCA (oral administration; 6 months; chow 8mg/kg body weight /day) restores cholesterol homeostasis in diabetic retina. It significantly increases endogenous LXR ligands, desmosterol, and total oxysterols in the diabetic retina[1].
DMHCA Preparation Products And Raw materials
Raw materials
Preparation Products
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