MBQ-167
- Product Name
- MBQ-167
- CAS No.
- 2097938-73-1
- Chemical Name
- MBQ-167
- Synonyms
- MBQ-167;MBQ 167;MBQ167;MBQ-167 ，S8749;MBQ-167, 10 mM in DMSO;9-Ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole;9H-Carbazole, 9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-;Cyclin dependent kinase,MBQ-167,MBQ167,MBQ 167,Inhibitor,inhibit,CDK,Ras
- CBNumber
- CB44718631
- Molecular Formula
- C22H18N4
- Formula Weight
- 338.41
- MOL File
- 2097938-73-1.mol
MBQ-167 Property
- Boiling point:
- 531.8±60.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO: Soluble
- form
- A solid
- pka
- -0.06±0.70(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0066907
- Product name
- MBQ-167
- Purity
- 99.26%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- Axon2777
- Product name
- MBQ-167
- Purity
- 98%
- Packaging
- 10mg
- Price
- $115.5
- Updated
- 2021/12/16
- Product number
- CS-0066907
- Product name
- MBQ-167
- Purity
- 99.26%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-0066907
- Product name
- MBQ-167
- Purity
- 99.26%
- Packaging
- 50mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- orb573215
- Product name
- MBQ-167
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
MBQ-167 Chemical Properties,Usage,Production
Uses
MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.
in vivo
MBQ-167-treated mice demonstrate a statistically significant reduction in tumor growth. At sacrifice, 1.0 mg/kg BW of MBQ-167 results in a ~80% reduction in tumor growth, and the 10 mg/kg BW MBQ-167 treatment results in ~95% reduction in tumor growth. Since EHop-016 only exerts ~40% reduction of tumor growth at 10 mg/kg BW, MBQ-167 is 10X more effective than EHop-016. MBQ-167 treated mice demonstrate similar doubling times for both treatments (10 and 11 days)[1].
IC 50
Cdc42: 78 nM (IC50); Ras 1/2/3: 103 nM (IC50)
References
[1] Humphries-Bickley T, et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 May;16(5):805-818. DOI:10.1158/1535-7163.MCT-16-0442
MBQ-167 Preparation Products And Raw materials
Raw materials
Preparation Products
MBQ-167 Suppliers
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