ChemicalBook > CAS DataBase List > Triazavirin

Triazavirin

Product Name: Triazavirin
CAS No.: 928659-17-0
Chemical Name: Triazavirin
Synonyms: Triazavirin;Triazavirin (TZV);Triazavirin (Riamilovir);Triazavirin, 10 mM in DMSO;Triazavirin sodium hydrate (TZV, Riamilovir);Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate;Sodium 7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-ide dihydrate;1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate;Inhibitor,DNA,influenza,transmission,encephalitis,antiviral,RNA,Triazavirin,DNA/RNA Synthesis,Nucleoside Antimetabolite/Analog,Tick-born,Influenza Virus,nucleoside,replication,inhibit
CBNumber: CB44763419
Molecular Formula: C5H7N6NaO4S
Formula Weight: 270.2
MOL File: 928659-17-0.mol

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Triazavirin Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 125 mg/mL (436.76 mM)
form: A solid
color: Light yellow to yellow
InChI: InChI=1S/C5H4N6O3S.Na.H2O.H/c1-15-5-6-4-8-7-2(11(13)14)3(12)10(4)9-5;;;/h1H3,(H,6,8,9);;1H2;
InChIKey: HSYOIVJKWAPORA-UHFFFAOYSA-N
SMILES: O=C1C(=NN=C2NC(SC)=NN12)N(=O)=O.[NaH].O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0016556
Product name: Triazavirin
Purity: 99.01%
Packaging: 5mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-0016556
Product name: Triazavirin
Purity: 99.01%
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0016556
Product name: Triazavirin
Purity: 99.01%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

DC Chemicals

Product number: DC21567
Product name: Triazavirin(Riamilovir)
Purity: >98%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

Ambeed

Product number: A1228484
Product name: Sodium7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-idedihydrate
Purity: 99+%
Packaging: 10mg
Price: $116
Updated: 2021/12/16

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Triazavirin Chemical Properties,Usage,Production

Uses

Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza[1].

Biological Activity

Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid, which inhibits the synthesis of viral RNA and DNA and the replication of genomic fragments. It is active against influenza and many other viruses, and acts as an effective protective agent during influenza transmission.

in vitro

The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain < i> Sofiin ) by accumulation in the SKEV cell culture.

in vivo

The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed.

target

Nucleoside analogue; Influenza virus

References

[1] Kozhikhova KV, et al. Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drug Triazavirin. Pharm Dev Technol. 2018 Apr;23(4):334-342. DOI:10.1080/10837450.2016.1242624
[2] Loginova SIa, et al. Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture. Antibiot Khimioter. 2014;59(1-2):3-5. PMID:25051708
[3] Loginova SY, et al. Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice. Antibiot Khimioter. 2015;60(7-8):11-3. PMID:26863736

Triazavirin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Triazavirin manufacturers

Hebei Ganmiao New material Technology Co., LTD

Product: Triazavirin 928659-17-0
Price: US $13.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200ton
Release date: 2024-06-19

Fuzhou Lista Biotechnology Co.,Ltd

Product: Triazavirin 928659-17-0
Price: US $55.00-40.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 2000kgs
Release date: 2024-07-26

928659-17-0, TriazavirinRelated Search:

Sodium bisulfite

Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate

1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate

Triazavirin

Sodium 7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-ide dihydrate

Triazavirin (Riamilovir)

Triazavirin sodium hydrate (TZV, Riamilovir)

Inhibitor,DNA,influenza,transmission,encephalitis,antiviral,RNA,Triazavirin,DNA/RNA Synthesis,Nucleoside Antimetabolite/Analog,Tick-born,Influenza Virus,nucleoside,replication,inhibit

Triazavirin, 10 mM in DMSO

Triazavirin (TZV)

928659-17-0

C5H7N6NaO5S

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