ChemicalBook > CAS DataBase List > CANDESARTAN-D4

CANDESARTAN-D4

Product Name: CANDESARTAN-D4
CAS No.: 1346604-70-3
Chemical Name: CANDESARTAN-D4
Synonyms: CV-11974-d4;CANDESARTAN-D4;[2H4]-Candesartan;Candesartan M1-d4;Candesartan D4 (CV-11974 D4);2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1-(phenyl-d4)-1'-phenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid;1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid;1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid;2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)(2,3,5,6-2H?)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid;Candesartan D4Q: What is Candesartan D4 Q: What is the CAS Number of Candesartan D4 Q: What is the storage condition of Candesartan D4
CBNumber: CB4477701
Molecular Formula: C24H16D4N6O3
Formula Weight: 444.48
MOL File: Mol file

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CANDESARTAN-D4 Property

Melting point:: 151-157°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25419
Product name: Candesartan-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 1mg
Price: $335
Updated: 2024/03/01

Cayman Chemical

Product number: 25419
Product name: Candesartan-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 5mg
Price: $669
Updated: 2024/03/01

Usbiological

Product number: 005550
Product name: Candesartan-d4
Packaging: 1mg
Price: $531
Updated: 2021/12/16

TRC

Product number: C175578
Product name: Candesartan-d4
Packaging: 25mg
Price: $3630
Updated: 2021/12/16

ChemScene

Product number: CS-4129
Product name: CandesartanD4
Purity: 98.85%
Packaging: 1mg
Price: $216
Updated: 2021/12/16

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CANDESARTAN-D4 Chemical Properties,Usage,Production

Description

Candesartan-d₄ is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an antagonist of the angiotensin II type 1 (AT₁) receptor (K_is = 0.17, 0.12, and 0.12 nM for human AT₁, rat AT_1A, and rat AT_1B recombinant receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489). It is selective for AT₁ over AT₂ receptors (K_i = 26,500 nM for the human recombinant AT₂ receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID₅₀ = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.

Chemical Properties

CANDESARTAN-D4 is White to Off-White Solid

Uses

CANDESARTAN-D4 is an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

Uses

Labelled Candesartan, an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

References

[1] Y. INADA S. C T Nakane*. Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors[J]. Fundamental & Clinical Pharmacology, 2002, 16 4: 317-323. DOI: 10.1046/j.1472-8206.2002.00076.x
[2] Y SHIBOUTA. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).[J]. Journal of Pharmacology and Experimental Therapeutics, 1993, 266 1: 114-120.

CANDESARTAN-D4 Preparation Products And Raw materials

Raw materials

Preparation Products

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1346604-70-3, CANDESARTAN-D4Related Search:

Octamethylcyclotetrasiloxane Candesartan

2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1-(phenyl-d4)-1'-phenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid

Candesartan M1-d4

CV-11974-d4

CANDESARTAN-D4

[2H4]-Candesartan

Candesartan D4Q: What is Candesartan D4 Q: What is the CAS Number of Candesartan D4 Q: What is the storage condition of Candesartan D4

Candesartan D4 (CV-11974 D4)

1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid

2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)(2,3,5,6-2H?)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid

1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid

1346604-70-3

C24H16D4N6O3

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Intermediates & Fine Chemicals

Isotope Labelled Compounds

Nucleotides

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