2-METHYL-1,3-BENZOTHIAZOL-6-OL
- Product Name
- 2-METHYL-1,3-BENZOTHIAZOL-6-OL
- CAS No.
- 68867-18-5
- Chemical Name
- 2-METHYL-1,3-BENZOTHIAZOL-6-OL
- Synonyms
- 2-METHYL-6-BENZOTHIAZOLOL;6-Benzothiazolol, 2-methyl-;2-methylbenzo[d]thiazol-6-ol;2-Methylbenzothiazol-6-ol,96%;2-METHYL-1,3-BENZOTHIAZOL-6-OL;2-Methylbenzothiazol-6-ol, 96%;6-HYDROXY-2-METHYLBENZOTHIAZOLE;6-Hydroxy-2-methylbenzothiazole 97%;6-Benzothiazolol,2-methyl-(6CI,7CI,9CI)
- CBNumber
- CB4479619
- Molecular Formula
- C8H7NOS
- Formula Weight
- 165.21
- MOL File
- 68867-18-5.mol
2-METHYL-1,3-BENZOTHIAZOL-6-OL Property
- Melting point:
- 159-161℃
- Boiling point:
- 28 °C(Press: 3 Torr)
- Density
- 1.365±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.68±0.40(Predicted)
- Appearance
- Off-white to gray Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M219810
- Product name
- 2-Methyl-1,3-benzothiazol-6-ol
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 135633
- Product name
- 2-Methylbenzo[d]thiazol-6-ol
- Purity
- 95%+
- Packaging
- 1g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- OR936497
- Product name
- 2-Methyl-1,3-benzothiazol-6-ol
- Purity
- 97%
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 135633
- Product name
- 2-Methylbenzo[d]thiazol-6-ol
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- OR936497
- Product name
- 2-Methyl-1,3-benzothiazol-6-ol
- Purity
- 97%
- Packaging
- 5g
- Price
- $320
- Updated
- 2021/12/16
2-METHYL-1,3-BENZOTHIAZOL-6-OL Chemical Properties,Usage,Production
Uses
2-Methyl-1,3-benzothiazol-6-ol is a useful reactant for the preparation of G protein-biased D2 dopamine receptor partial agonists.
Synthesis
2941-72-2
68867-18-5
The general procedure for the synthesis of 2-methyl-6-hydroxybenzothiazole from 6-methoxy-2-methylbenzothiazole is as follows: to a dichloromethane solution (10 ml) of 6-methoxy-2-methylbenzothiazole (500 mg, 2.79 mmol) was slowly added to a dichloromethane solution (8.4 ml, 8.40 mmol) of boron bromide (8.4 ml) at -78°C and under nitrogen protection . The reaction mixture was then warmed to 0°C and stirred continuously at this temperature for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water to the reaction mixture, followed by extraction with dichloromethane. The combined organic phases were washed sequentially with saturated aqueous sodium bicarbonate and pure water, followed by drying with anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure and the resulting crude product was purified by medium pressure preparative liquid chromatography (Yamazen Corporation, W-Prep 2XY) to give 2-methyl-6-hydroxybenzothiazole (103 mg, 22% yield) as a colorless oil. The structure of the product was confirmed by 1H-NMR (CDCl3, 400 MHz) and mass spectrometry (ESI): 1H-NMR δ 7.66 (1H, d, J = 8.8 Hz), 7.23 (1H, d, J = 2.4 Hz), 6.94 (1H, dd, J = 8.8 Hz, 2.4 Hz), 2.74 (3H, s); MS (ESI, m/z). 166 (M + H)+.
References
[1] Helvetica Chimica Acta, 1992, vol. 75, # 4, p. 1185 - 1197
[2] Patent: EP2258697, 2010, A1. Location in patent: Page/Page column 117
[3] Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1158,1159, 1164; engl. Ausg. S. 1153, 1154,1159
[4] Sb. Statei Obshch. Khim., 1953, p. 1263,1264, 1266, 1271
[5] Chem.Abstr., 1955, p. 5443
2-METHYL-1,3-BENZOTHIAZOL-6-OL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-METHYL-1,3-BENZOTHIAZOL-6-OL manufacturers
- Product
- 2-METHYL-1,3-BENZOTHIAZOL-6-OL 68867-18-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18