DMU2139
- Product Name
- DMU2139
- CAS No.
- 1821143-80-9
- Chemical Name
- DMU2139
- Synonyms
- CYP1B1 inhibitor;DMU2139(CYP1B1 inhibitor 6j);DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9;(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one;2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
- CBNumber
- CB44796646
- Molecular Formula
- C19H15NO2
- Formula Weight
- 289.33
- MOL File
- 1821143-80-9.mol
DMU2139 Property
- Boiling point:
- 488.6±45.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO:77.5(Max Conc. mg/mL);267.86(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);17.28(Max Conc. mM) - pka
- 3.80±0.11(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0021084
- Product name
- DMU2139
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0021084
- Product name
- DMU2139
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-0021084
- Product name
- DMU2139
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0021084
- Product name
- DMU2139
- Purity
- >98.0%
- Packaging
- 100mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- AA01EODY
- Product name
- DMU2139
- Purity
- 98%
- Packaging
- 100mg
- Price
- $1369
- Updated
- 2021/12/16
DMU2139 Chemical Properties,Usage,Production
Biological Activity
DMU2139 is a potent and specific cytochrome P4501B1 (CYP1B1) inhibitor with IC50 values of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
in vitro
DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC 50 is reversed back to 8.3 μM from 61 μM ( seen in CYP1B1-expressing cells without any inhibitor). The EC 50 value, in the presence of DMU2139, resembles the EC 50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein.
target
| CYP1B1 9 nM (IC 50 ) | CYP1A1 795 nM (IC 50 ) |
DMU2139 Preparation Products And Raw materials
Raw materials
Preparation Products
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