DMU2139

Product Name: DMU2139
CAS No.: 1821143-80-9
Chemical Name: DMU2139
Synonyms: CYP1B1 inhibitor;DMU2139(CYP1B1 inhibitor 6j);DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9;(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one;2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
CBNumber: CB44796646
Molecular Formula: C19H15NO2
Formula Weight: 289.33
MOL File: 1821143-80-9.mol

More

Less

DMU2139 Property

Boiling point:: 488.6±45.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO:77.5(Max Conc. mg/mL);267.86(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);17.28(Max Conc. mM)
pka: 3.80±0.11(Predicted)
form: Solid
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0021084
Product name: DMU2139
Purity: >98.0%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0021084
Product name: DMU2139
Purity: >98.0%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-0021084
Product name: DMU2139
Purity: >98.0%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0021084
Product name: DMU2139
Purity: >98.0%
Packaging: 100mg
Price: $1200
Updated: 2021/12/16

aablocks

Product number: AA01EODY
Product name: DMU2139
Purity: 98%
Packaging: 100mg
Price: $1369
Updated: 2021/12/16

More

Less

DMU2139 Chemical Properties,Usage,Production

Uses

DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

Biological Activity

DMU2139 is a potent and specific cytochrome P4501B1 (CYP1B1) inhibitor with IC50 values of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

in vitro

DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC ₅₀ is reversed back to 8.3 μM from 61 μM ( seen in CYP1B1-expressing cells without any inhibitor). The EC ₅₀ value, in the presence of DMU2139, resembles the EC ₅₀ of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein.

target

CYP1B1

9 nM (IC ₅₀ )

CYP1A1

795 nM (IC ₅₀ )

IC 50

CYP1B1: 9 nM (IC₅₀); CYP1A1: 795 nM (IC₅₀)

References

[1] Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. DOI:10.1016/j.ejmech.2017.02.016

DMU2139 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

DMU2139 Suppliers

China 25 India 1 United States 4 Global 30

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2961
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10408
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 14013
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1985
Advantage: 58

1821143-80-9, DMU2139Related Search:

(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one

DMU2139(CYP1B1 inhibitor 6j)

CYP1B1 inhibitor

DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9

2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-

1821143-80-9

API