ChemicalBook > CAS DataBase List > DMU2139

DMU2139

Product Name
DMU2139
CAS No.
1821143-80-9
Chemical Name
DMU2139
Synonyms
CYP1B1 inhibitor;DMU2139(CYP1B1 inhibitor 6j);DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9;(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one;2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
CBNumber
CB44796646
Molecular Formula
C19H15NO2
Formula Weight
289.33
MOL File
1821143-80-9.mol
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DMU2139 Property

Boiling point:
488.6±45.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO:77.5(Max Conc. mg/mL);267.86(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);17.28(Max Conc. mM)
pka
3.80±0.11(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0021084
Product name
DMU2139
Purity
>98.0%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0021084
Product name
DMU2139
Purity
>98.0%
Packaging
10mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-0021084
Product name
DMU2139
Purity
>98.0%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0021084
Product name
DMU2139
Purity
>98.0%
Packaging
100mg
Price
$1200
Updated
2021/12/16
aablocks
Product number
AA01EODY
Product name
DMU2139
Purity
98%
Packaging
100mg
Price
$1369
Updated
2021/12/16
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DMU2139 Chemical Properties,Usage,Production

Biological Activity

DMU2139 is a potent and specific cytochrome P4501B1 (CYP1B1) inhibitor with IC50 values of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

in vitro

DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC 50 is reversed back to 8.3 μM from 61 μM ( seen in CYP1B1-expressing cells without any inhibitor). The EC 50 value, in the presence of DMU2139, resembles the EC 50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein.

target

CYP1B1

9 nM (IC 50 )

CYP1A1

795 nM (IC 50 )

DMU2139 Preparation Products And Raw materials

Raw materials

Preparation Products

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DMU2139 Suppliers

China 20 India 1 United States 4 Global 25
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1821143-80-9, DMU2139Related Search:


  • (E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one
  • DMU2139(CYP1B1 inhibitor 6j)
  • CYP1B1 inhibitor
  • DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9
  • 2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
  • 1821143-80-9
  • API