E3 ligase Ligand-Linker Conjugates 6 Free Base

Product Name: E3 ligase Ligand-Linker Conjugates 6 Free Base
CAS No.: 2010159-60-9
Chemical Name: E3 ligase Ligand-Linker Conjugates 6 Free Base
Synonyms: AHPC-PEG2-NH2;VH032-PEG2-NH2;S)-AHPC-PEG2-NH2;(S,R,S)-AHPC-PEG2-NH2;PROTACs Related Compound 6;VHL Ligand-Linker Conjugates 3;（S,R,S)-AHPC-acetamido-O-C2-amine HCI;(S,R. S)-AHPC-PEG2-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 6 Free Base;(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)
CBNumber: CB44797052
Molecular Formula: C28H41N5O6S
Formula Weight: 575.73
MOL File: 2010159-60-9.mol

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E3 ligase Ligand-Linker Conjugates 6 Free Base Property

Boiling point:: 856.9±65.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, Methanol
pka: 13.54±0.46(Predicted)
form: Solid
color: Off-white to light yellow

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24451
Product name: (S,R.S)-AHPC-PEG2-aminehydrochloridesalt
Purity: 98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

DC Chemicals

Product number: 027596
Product name: (S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase)
Packaging: 001
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: 027596
Product name: (S,R,S)-AHPC-PEG2-NH2(E3ligaseLigand-LinkerConjugates6FreeBase)
Packaging: 002
Price: $950
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 6 Free Base Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-PEG2-amine is a synthetic PROTAC linker that incorporates an E3 ligase ligand with a PEG2 unit to empower drug research & discovery. It is reactive with NHS ester or carboxylic acid.

Uses

(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs[1].

IC 50

VHL

References

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Me DOI:10.1021/acs.jmedchem.6b01912

E3 ligase Ligand-Linker Conjugates 6 Free Base Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 6 Free Base Suppliers

China 26 United States 2 Global 28

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7440
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Aikon International Limited

Tel: 025-58859352 19370895928
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15082
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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Shanghai SPAR pharmaceutical technology co., LTD

Tel: 021-000000
Email: admin@jingshipharmatech.com
Country: China
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Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1634
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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Zhengzhou Akem Chemical Co., Ltd

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Email: 3001317055@qq.com
Country: China
ProdList: 9800
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Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 39807
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 5061
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Wuhan Yuxiang Medical Technology Co., Ltd.

Tel: 13971275651
Email: sales@whyxpharma.com
Country: China
ProdList: 1837
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 6 Free Base manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG2-NH2 2010159-60-9
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2010159-60-9, E3 ligase Ligand-Linker Conjugates 6 Free BaseRelated Search:

E3 ligase Ligand-Linker Conjugates 6 Free Base

(2S,4R)-1-[(2S)-2-[[2-[2-(2-aminoethoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

(S,R,S)-AHPC-PEG2-NH2

VH032-PEG2-NH2

VHL Ligand-Linker Conjugates 3

PROTACs Related Compound 6

(S,R. S)-AHPC-PEG2-amine hydrochloride salt

(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)

（S,R,S)-AHPC-acetamido-O-C2-amine HCI

(2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

S)-AHPC-PEG2-NH2

(S,R,S) AHPC PEG2 NH2,Inhibitor,E3 ligase Ligand-Linker Conjugates 6,inhibit,(S,R,S)AHPCPEG2NH2,(S,R,S)-AHPC-PEG-2-NH2,E3 Ligase Ligand-Linker Conjugates

(2S,4R)-1-[(2S)-2-{2-[2-(2-aminoethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

AHPC-PEG2-NH2

2010159-60-9

C28H41N5O6S