ChemicalBook > CAS DataBase List > RGX-104 free Acid

RGX-104 free Acid

Product Name
RGX-104 free Acid
CAS No.
610318-54-2
Chemical Name
RGX-104 free Acid
Synonyms
SB742881;RGX-104 free Acid;RGX-104 (free form);RGX-104, 10 mM in DMSO;Abequolixron (RGX-104);RGX-104freeAcid/SB742881;610318-54-2 (FREE FORM) 610318-03-1 (HCL);RGX 104,inhibit,LXR,RGX-104,Liver X receptor,RGX104,Inhibitor;(R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid;Benzeneacetic acid, 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-
CBNumber
CB44808622
Molecular Formula
C34H33ClF3NO3
Formula Weight
596.08
MOL File
610318-54-2.mol
More
Less

RGX-104 free Acid Property

Boiling point:
677.1±55.0 °C(Predicted)
Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO:100.0(Max Conc. mg/mL);167.76(Max Conc. mM)
form 
Solid
pka
4.19±0.10(Predicted)
color 
White to off-white
InChIKey
ZLJZDYOBXVOTSA-XMMPIXPASA-N
SMILES
C1(CC(O)=O)=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C2=CC=CC=C2)C2=CC=CC=C2)C)=C1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0080747
Product name
RGX-104freeAcid
Purity
99.97%
Packaging
2mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0080747
Product name
RGX-104freeAcid
Purity
99.97%
Packaging
5mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0080747
Product name
RGX-104freeAcid
Purity
99.97%
Packaging
10mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-0080747
Product name
RGX-104freeAcid
Purity
99.97%
Packaging
25mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-0080747
Product name
RGX-104freeAcid
Purity
99.97%
Packaging
50mg
Price
$850
Updated
2021/12/16
More
Less

RGX-104 free Acid Chemical Properties,Usage,Production

Uses

RGX-104 is combination of a liver X receptor β agonist and GITR modulator for treatment of cancer.Liver X receptor beta agonist.

in vivo

Oral administration of RGX-104 (100 mg/kg, daily) to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Co-administration of RGX-104 with anti-PD-1 is superior to administration of either RGX-104 or anti-PD-1 alone. Importantly, co-administration of RGX-104 with anti-PD-1 therapy is well tolerated by mice, with no overt signs of toxicity[1].

Animal Model:NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells[1].
Dosage:100 mg/kg.
Administration:Oral administration daily for about 60 days.
Result:Robustly suppressed tumor growth and progression.

RGX-104 free Acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

RGX-104 free Acid Suppliers

CHINA 42 India 1 United States 3 Global 46
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2986
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.
Tel
63313187 15358055255
Fax
QQ：63313187
Email
63313187@qq.com
Country
China
ProdList
1984
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.
Tel
022-23989838 13810451150
Email
44766350@qq.com
Country
China
ProdList
2348
Advantage
58

610318-54-2, RGX-104 free AcidRelated Search:


  • RGX-104 free Acid
  • 610318-54-2 (FREE FORM) 610318-03-1 (HCL)
  • RGX-104 (free form)
  • SB742881
  • Benzeneacetic acid, 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-
  • RGX-104freeAcid/SB742881
  • Abequolixron (RGX-104)
  • (R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid
  • RGX 104,inhibit,LXR,RGX-104,Liver X receptor,RGX104,Inhibitor
  • RGX-104, 10 mM in DMSO
  • 610318-54-2
  • C34H33ClF3NO3