ChemicalBook > CAS DataBase List > 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE

1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE

Product Name
1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE
CAS No.
4101-32-0
Chemical Name
1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE
Synonyms
1-(4,5-dimethoxy-2-nitrophenyl)ethan-1-one;1-(4,5-Dimethoxy-2-nitrophenyL;3,4-Dimethoxy-2-nitroacetophenone;4',5'-Dimethoxy-2'-nitroacetophenone;3',4'-DIMETHOXY-6'-NITROACETOPHENONE;2'-NITRO-4',5'-DIMETHOXYACETOPHENONE;1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE;Ethanone, 1-(4,5-dimethoxy-2-nitrophenyl)-;4',5'-Dimethoxy-2'-nitroacetophenone4101-32-0
CBNumber
CB4483726
Molecular Formula
C10H11NO5
Formula Weight
225.2
MOL File
4101-32-0.mol
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1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE Property

Melting point:
133.5-135 °C
Boiling point:
389.2±37.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
color 
Light orange to Yellow to Green
InChI
InChI=1S/C10H11NO5/c1-6(12)7-4-9(15-2)10(16-3)5-8(7)11(13)14/h4-5H,1-3H3
InChIKey
ZVLFGESHYMKNQP-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC(OC)=C(OC)C=C1[N+]([O-])=O)C
EPA Substance Registry System
Ethanone, 1-(4,5-dimethoxy-2-nitrophenyl)- (4101-32-0)
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Safety

HS Code 
2913.00.4000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5477
Product name
4',5'-Dimethoxy-2'-nitroacetophenone
Purity
>98.0%(GC)
Packaging
1g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
D5477
Product name
4',5'-Dimethoxy-2'-nitroacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$249
Updated
2025/07/31
TRC
Product number
D654153
Product name
1-(4,5-Dimethoxy-2-nitrophenyl)ethanone
Packaging
100mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70399
Product name
3',4'-Dimethoxy-6'-nitroacetophenone
Packaging
2g
Price
$90
Updated
2021/12/16
Chem-Impex
Product number
27943
Product name
2'-Nitro-4',5'-dimethoxyacetophenone,≥98%(GC)
Purity
≥98%(GC)
Packaging
5G
Price
$99.01
Updated
2021/12/16
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1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 55, p. 1585, 1990 DOI: 10.1021/jo00292a038

Synthesis

1131-62-0

4101-32-0

General procedure for the synthesis of 1-(4,5-dimethoxy-2-nitrophenyl)ethanone from 3,4-dimethoxyacetophenone: (1) Nitration step: a solution was prepared by dissolving 3,4-dimethoxyacetophenone (1,500 g) in 17% nitric acid (1,400 g) at 5 to 10 °C, followed by slow dropwise addition to a solution consisting of 67% nitric acid (8430 g) and sodium nitrite (18 g) (18 g). The titration process was controlled to be completed within 2 to 3 hours. After the dropwise addition, the reaction solution was continued to be stirred at 5 to 10°C for 1 to 2 hours. Cold water (7.5 L) was added to dilute the reaction mixture and stirred for 30 minutes. The reaction mixture was filtered and the filter cake was washed with water (30 L). The solid product obtained by filtration was re-suspended in water (7.5 L), neutralized with aqueous sodium bicarbonate to pH neutral, filtered again and washed with water (7 L). Finally, the product was dried under reduced pressure to afford 3,4-dimethoxy-6-nitroacetophenone (2164 g, 87.9% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 2.50 (s, 3H), 3.97 (s, 3H), 3.99 (s, 3H), 6.76 (s, 1H), 7.62 (s, 1H).

References

[1] Patent: EP1559715, 2005, A1. Location in patent: Page/Page column 17
[2] Heterocycles, 2016, vol. 92, # 10, p. 1882 - 1887
[3] Chemistry Letters, 2000, # 7, p. 712 - 713
[4] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0354; 0355
[5] Journal of Organic Chemistry, 1999, vol. 64, # 21, p. 7988 - 7995

1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE 4101-32-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-17
Suzhou Nordica Biopharma CO.,LTD
Product
4,5-dimethoxy-2-nitroacetophenone 4101-32-0
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
0.99
Supply Ability
1 tons
Release date
2024-11-15
Shaanxi Dideu Medichem Co. Ltd
Product
3,4-Dimethoxy-2-nitroacetophenone 4101-32-0
Price
US $30.00-20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-05

4101-32-0, 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONERelated Search:

1-(3,4,5-Trimethoxy-2-nitrophenyl)ethanone 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE (4-CHLORO-PHENYL)-(4,5-DIMETHOXY-2-NITRO-PHENYL)-METHANONE 2-BROMO-1-(4,5-DIMETHOXY-2-NITRO-PHENYL)ETHANONE 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-PROPAN-1-ONE (4,5-DIMETHOXY-2-NITRO-PHENYL)-FURAN-2-YL-METHANONE 1-(7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-2-PHENYL-ETHANONE (4,5-DIMETHOXY-2-NITRO-PHENYL)-(5-METHYL-FURAN-2-YL)-METHANONE FURAN-2-YL-(7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-METHANONE 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-2-PHENYL-ETHANONE (7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-PHENYL-METHANONE (2,4-DICHLORO-PHENYL)-(4,5-DIMETHOXY-2-NITRO-PHENYL)-METHANONE (7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-P-TOLYL-METHANONE (4-BROMO-PHENYL)-(4,5-DIMETHOXY-2-NITRO-PHENYL)-METHANONE (3-BROMO-PHENYL)-(7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-METHANONE 1-(7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-ETHANONE (4,5-DIMETHOXY-2-NITRO-PHENYL)-PHENYL-METHANONE (4,5-DIMETHOXY-2-NITRO-PHENYL)-P-TOLYL-METHANONE

  • 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE
  • 2'-NITRO-4',5'-DIMETHOXYACETOPHENONE
  • 3',4'-DIMETHOXY-6'-NITROACETOPHENONE
  • 1-(4,5-dimethoxy-2-nitrophenyl)ethan-1-one
  • 4',5'-Dimethoxy-2'-nitroacetophenone
  • Ethanone, 1-(4,5-dimethoxy-2-nitrophenyl)-
  • 1-(4,5-Dimethoxy-2-nitrophenyL
  • 3,4-Dimethoxy-2-nitroacetophenone
  • 4',5'-Dimethoxy-2'-nitroacetophenone4101-32-0
  • 4101-32-0
  • 4010-32-0
  • Aromatic Acetophenones & Derivatives (substituted)