FEN1-IN-1
- Product Name
- FEN1-IN-1
- CAS No.
- 824983-91-7
- Chemical Name
- FEN1-IN-1
- Synonyms
- LNT 1;FEN1-IN-1;FEN1 inhibitor 1;EN1 Inhibitor C1;LNT 1 (FEN1-IN-1);FEN1 IN 1,FEN-1-IN-1,inhibit,Inhibitor,FEN1IN1;1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione;1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione;Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-;1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
- CBNumber
- CB44844767
- Molecular Formula
- C15H12N2O5S
- Formula Weight
- 332.33
- MOL File
- 824983-91-7.mol
FEN1-IN-1 Property
- Boiling point:
- 548.9±52.0 °C(Predicted)
- Density
- 1.583±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (15 mg/ml)
- pka
- 7.91±0.20(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6510
- Product name
- LNT1
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $197
- Updated
- 2021/12/16
- Product number
- Axon3027
- Product name
- FEN1inhibitor1-LNT1
- Purity
- 99%
- Packaging
- 25mg
- Price
- $522.5
- Updated
- 2021/12/16
FEN1-IN-1 Chemical Properties,Usage,Production
Description
LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4
storage
Store at -20°C
References
Tumey et al. (2005), The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors; Med. Chem. Lett., 15 277 Exell et al. (2016), Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site; Chem. Biol., 12 815 Ward et al. (2017), Small molecules inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes; PLoS One, 12 e0179278 Guo et al. (2020), FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination; Natl. Acad. Sci USA 117 19415
FEN1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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