HS-10296 hydrochloride

Product Name: HS-10296 hydrochloride
CAS No.: 2134096-03-8
Chemical Name: HS-10296 hydrochloride
Synonyms: HS-10296 hydrochloride;Almonertinib (hydrochloride);Almonertinib (HS-10296) hydrochloride;N-(5-((4-(1-CYCLOPROPYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-((2-(DIMETHYLAMINO)ETHYL)(METHYL)AMINO)-4-METHOXYPHENYL)ACRYLAMIDE HYDROCHLORIDE;HS10296,EGFR,non-small,inhibit,oral,cancer,lung,del19,antineoplastic,HS-10296,mutations,Epidermal growth factor receptor,L861Q,Almonertinib hydrochloride,G719X,Inhibitor,NSCLC,ErbB-1,L858R,cell,Almonertinib,HS 10296,HER1
CBNumber: CB44844873
Molecular Formula: C30H36ClN7O2
Formula Weight: 562.12
MOL File: 2134096-03-8.mol

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HS-10296 hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO:83.33(Max Conc. mg/mL);148.24(Max Conc. mM)
form: Solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0080793
Product name: Almonertinibhydrochloride
Purity: 98.05%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0080793
Product name: Almonertinibhydrochloride
Purity: 98.05%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0080793
Product name: Almonertinibhydrochloride
Purity: 98.05%
Packaging: 25mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0080793
Product name: Almonertinibhydrochloride
Purity: 98.05%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

ChemScene

Product number: CS-0080793
Product name: Almonertinibhydrochloride
Purity: 98.05%
Packaging: 100mg
Price: $1450
Updated: 2021/12/16

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HS-10296 hydrochloride Chemical Properties,Usage,Production

Description

HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

in vitro

HS-10296 significantly inhibited the proliferation of MDA-MB-231 cells with IC50 values at 24, 48 and 72 h of 8.393, 2.777 and 2.016 μmol/L, respectively. JC-1 and flow cytometry showed that HS-10296 induced obvious apoptosis of MDA-MB-231 cells, which showed an apoptosis rate of (21.63 ± 2.97)% following treatment with 8 μmol/L HS-10296. _x000D_ _x000D_ Reference: Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jul 30;40(7):981-987. https://pubmed.ncbi.nlm.nih.gov/32895156/

in vivo

Western blotting showed that compared with the control group, the expression levels of MMP-9, MMP-2 and vimentin protein in PC-9 and H1975 cells in 1, 2 and 4 μmol/L almonertinib treatment group were significantly lower, and the expression level of E-cadherin protein was significantly higher (all P<0.05). The experimental results of nude mice showed that compared with the control group and the positive control ositinib (AZD9291) group, the tumor growth was significantly inhibited, the weight of nude mice, the tumor volume and the tumor mass were significantly reduced in the almonertinib treatment group (all P<0.05)._x000D_ _x000D_ Reference: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Oct 28;46(10):1045-1053. https://pubmed.ncbi.nlm.nih.gov/34911833/

target

Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM).

HS-10296 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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HS-10296 hydrochloride Suppliers

China 20 United States 4 Global 24

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
Advantage: 56

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6464
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7316
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

2134096-03-8, HS-10296 hydrochlorideRelated Search:

HS-10296 hydrochloride

N-(5-((4-(1-CYCLOPROPYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-((2-(DIMETHYLAMINO)ETHYL)(METHYL)AMINO)-4-METHOXYPHENYL)ACRYLAMIDE HYDROCHLORIDE

Almonertinib (hydrochloride)

Almonertinib (HS-10296) hydrochloride

HS10296,EGFR,non-small,inhibit,oral,cancer,lung,del19,antineoplastic,HS-10296,mutations,Epidermal growth factor receptor,L861Q,Almonertinib hydrochloride,G719X,Inhibitor,NSCLC,ErbB-1,L858R,cell,Almonertinib,HS 10296,HER1

2134096-03-8