DBCO-PEG5-NHS ester

Product Name: DBCO-PEG5-NHS ester
CAS No.: 2144395-59-3
Chemical Name: DBCO-PEG5-NHS ester
Synonyms: 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB44849429
Molecular Formula: C36H43N3O11
Formula Weight: 693.74
MOL File: 2144395-59-3.mol

More

Less

DBCO-PEG5-NHS ester Property

solubility: Soluble in DMSO, DCM, DMF
form: Oil
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

BroadPharm

Product number: BP-24055
Product name: DBCO-PEG5-NHSester
Purity: 96%
Packaging: 25mg
Price: $170
Updated: 2021/12/16

BroadPharm

Product number: BP-24055
Product name: DBCO-PEG5-NHSester
Purity: 96%
Packaging: 100mg
Price: $480
Updated: 2021/12/16

BroadPharm

Product number: BP-24055
Product name: DBCO-PEG5-NHSester
Purity: 96%
Packaging: 500mg
Price: $1650
Updated: 2021/12/16

More

Less

DBCO-PEG5-NHS ester Chemical Properties,Usage,Production

Description

DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.

Biological Activity

DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

Alkyl/ether

PEGs

DBCO-PEG5-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

DBCO-PEG5-NHS ester Suppliers

China 24 United States 4 Global 28

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q3252066219
Fax: QQ3382968513
Email: danping@shsendpharm.com
Country: China
ProdList: 3130
Advantage: 55

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3983
Advantage: 55

Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
ProdList: 1245
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4824
Advantage: 58

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 029-86217788 13892832556
Email: 2440688701@qq.com
Country: China
ProdList: 1993
Advantage: 58

Shaanxi borno biotechnology co., LTD

Tel: +86-13759708231
Email: asherw9@hotmail.com
Country: China
ProdList: 2350
Advantage: 58

Hangzhou Taorui Biotechnology Co., Ltd

Tel: 4000-360-990 15268198094
Email: sales@torreybio.com
Country: China
ProdList: 2869
Advantage: 58

Zhengzhou Akem Chemical Co., Ltd

Tel: 13303867194
Email: 3001317055@qq.com
Country: China
ProdList: 9992
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40037
Advantage: 58

Affinity（Wuhan）Ltd.

Tel: 15841022315
Email: sales@affinitytech.cn
Country: China
ProdList: 2629
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 5061
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29794
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564
Email: August@easycdmo.com
Country: China
ProdList: 10030
Advantage: 58

Xinyanpomei

Tel: 15850660754
Email: 15850660754@163.com
Country: China
ProdList: 173
Advantage: 58

Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.

Tel: 13771642864
Fax: 1078336263
Email: snhuyu_2008@126.com
Country: China
ProdList: 1111
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 25830
Advantage: 58

Xian confluore Biological Technology Co., Ltd.

Tel: +86-15680926068 +86-15680926068
Email: 1924344760@confluore.cn
Country: China
ProdList: 2995
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: +undefined18143011203
Email: info@chemextension.com
Country: China
ProdList: 42056
Advantage: 58

Shanghai Huici Pharmaceutical Technology Co., LTD

Tel: +8618917134367
Email: lixing@pharmahuici.com
Country: China
ProdList: 133
Advantage: 58

Shanghai Huici Pharmaceutical Technology Co., LTD

Tel: +8618917134367
Email: lixing@pharmahuici.com
Country: China
ProdList: 133
Advantage: 58

More

Less

View Lastest Price from DBCO-PEG5-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-PEG5-NHS ester 2144395-59-3
Price: US $0.00/mg
Min. Order: 50mg
Purity: >99.00%
Supply Ability: 250mg
Release date: 2024-03-20

2144395-59-3, DBCO-PEG5-NHS esterRelated Search:

DBCO-PEG5-CH2CH2COOH DBCO-PEG5-GGG-NH2 DBCO-PEG5-Acrylate

4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester

2144395-59-3

C36H43N3O11