DBCO-PEG5-NHS ester

Product Name: DBCO-PEG5-NHS ester
CAS No.: 2144395-59-3
Chemical Name: DBCO-PEG5-NHS ester
Synonyms: 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB44849429
Molecular Formula: C36H43N3O11
Formula Weight: 693.74
MOL File: 2144395-59-3.mol

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DBCO-PEG5-NHS ester Property

solubility: Soluble in DMSO, DCM, DMF
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24055
Product name: DBCO-PEG5-NHSester
Purity: 96%
Packaging: 25mg
Price: $170
Updated: 2021/12/16

BroadPharm

Product number: BP-24055
Product name: DBCO-PEG5-NHSester
Purity: 96%
Packaging: 100mg
Price: $480
Updated: 2021/12/16

BroadPharm

Product number: BP-24055
Product name: DBCO-PEG5-NHSester
Purity: 96%
Packaging: 500mg
Price: $1650
Updated: 2021/12/16

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DBCO-PEG5-NHS ester Chemical Properties,Usage,Production

Description

DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.

Biological Activity

DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

Alkyl/ether

PEGs

DBCO-PEG5-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG5-NHS ester Suppliers

China 23 United States 3 Global 26

Shanghai Send Pharmaceutical Technology Co., Ltd.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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Shanghai Huici Pharmaceutical Technology Co., LTD

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View Lastest Price from DBCO-PEG5-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-PEG5-NHS ester 2144395-59-3
Price: US $0.00/mg
Min. Order: 50mg
Purity: >99.00%
Supply Ability: 250mg
Release date: 2024-03-20

2144395-59-3, DBCO-PEG5-NHS esterRelated Search:

DBCO-PEG5-CH2CH2COOH DBCO-PEG5-GGG-NH2 DBCO-PEG5-Acrylate

4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester

2144395-59-3

C36H43N3O11